ArticleScientific reports2026
Silicone elastomer films loaded with 5-fluorouracil for time-dependent drug release.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Silicone elastomer composite films loaded with the antitumor drug 5-fluorouracil (5-FU) were developed for controlled release applications. Polydimethylsiloxane (PDMSOH) films were crosslinked using tetraethoxysilane and room-temperature vulcanization catalysts, with glycerol incorporated as a hydrophilic modifier to regulate permeability of the hydrophobic silicone matrix. Dimethyl sulfoxide was used to solubilize 5-FU during film preparation. Film microstructure and drug distribution were analyzed by scanning electron microscopy and Raman spectroscopic imaging. Among the tested formulations, the film containing 30 wt.% glycerol (F-4) exhibited uniform drug distribution and the most favorable 5-FU release profile in 0.9% NaCl solution, consistent with its morphological characteristics. Cytotoxicity and cytocompatibility were assessed in A549 and HepG2 cells using an ISO 10993-5 extract test. Extracts from the blank F-4 film were minimal cytotoxic across all extraction times, whereas extracts from the 5-FU-loaded F-4 film produced a time-dependent reduction in cell viability in both cell lines. The extract-mediated cytotoxicity closely followed the UV-Vis release profile, indicating that the biological response was predominantly driven by time-dependent 5-FU release rather than film-derived leachables. Overall, glycerol-modified PDMSOH films provide a tunable platform for sustained 5-FU delivery.
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