Evidence map›Paper›PMID 42218275›Full record

ArticleScientific reports2026

Physical function impacts hearing without mediation from systolic blood pressure.

Jean Neils-Strunjas, Meisam Arjmandi, Morteza Hajihosseini, Nicholas Riccardi, Cara Vandergriff, Mike Leonard, Sarah Newman-Norlund, Samaneh Nemati, Samin Ashjaei, Laura Droege and 6 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jean Neils-StrunjasDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA. neilsstj@mailbox.sc.edu.
Meisam ArjmandiDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA.
Morteza HajihosseiniSchool of Public Health, University of Alberta, Edmonton, AB, Canada.
Nicholas RiccardiDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA.
Cara VandergriffDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA.
Mike LeonardDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA.
Sarah Newman-NorlundDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA.
Samaneh NematiDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA.
Samin AshjaeiDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA.
Laura DroegeDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA.
Nadra SalmanDepartment of Linguistics, University of South Carolina, Columbia, USA.
Lorie DonelleSchool of Nursing, University of South Carolina, Columbia, USA.
Kesheng WangSchool of Nursing, University of South Carolina, Columbia, USA.
Daniela B FriedmanDepartment of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, USA.
Leonardo BonilhaSchool of Medicine, University of South Carolina, Columbia, USA.
Julius FridrikssonDepartment of Communication Sciences and Disorders, Arnold School of Public Health, 1705 College Street, Room 215, Columbia, SC, 29208, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The common cause theory of age-related hearing loss and age-related disorders of cognition suggests that there are shared underlying physiological variables that may be modified with intervention. This study examined the interrelationships among physical function (PF), systolic blood pressure (SBP), hearing, and cognition in 150 adults aged 50-80 years old, utilizing a Bayesian generalized structural equation modeling approach. The findings suggest that every 10-point increase in PF results in a decrease of hearing threshold by 1.35 dB HL (95% CrI: -0.232, -0.038) independent of SBP, while every 10-year increase in age increases SBP by 7.5 mm Hg (95% CrI: 0.417, 1.098) and increases hearing threshold by 8.78 dB HL (95% CrI: 0.608, 1.152). This indicates a more active lifestyle is associated with better hearing and that while SBP increases with age, it does not mediate the relationship between PF and hearing. Sex differences were observed in hearing outcomes, with males exhibiting poorer hearing. Additionally, there was only a minimal effect of PF on cognition, and this modest improvement was not explained by systolic blood pressure in our analytical sample. These results underscore the complexity of the pathways linking cardiovascular health, sensory function, and cognitive aging. The lack of mediation by SBP highlights the importance of targeting PF directly, rather than relying solely on blood pressure management for preserving auditory and cognitive health.

Indexed as

Blood PressureHearingAgedAged, 80 and overAgingAuditory AcuityBayes TheoremCognitionFemaleHearing LossHumansMaleMiddle AgedAge-related hearing lossCognitive functionMediation analysisOlder adultsPhysical functionSystolic blood pressure

Identifiers

PMID42218275
PMCPMC13454284

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.