Evidence map›Paper›PMID 42218273›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Reversible alterations of brain acetate metabolism associated with alcohol consumption.

Chathura Kumaragamage, Lihong Jiang, Gustavo A Angarita, Robin A de Graaf, Elizabeth Guidone, Anastasia Coppoli, Kevin L Behar, Barbara I Gulanski, Brian Pittman, Stuart A Weinzimer and 3 more

Abstract read
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In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chathura Kumaragamage *Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0003-1251-7819
Lihong Jiang *Department of Radiology and Biomedical Imaging, Yale Biomedical Imaging Institute, Magnetic Resonance Research Center, New Haven, CT, USA.
Gustavo A AngaritaDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-5568-9878
Robin A de GraafDepartment of Radiology and Biomedical Imaging, Yale Biomedical Imaging Institute, Magnetic Resonance Research Center, New Haven, CT, USA.
Elizabeth GuidoneDepartment of Radiology and Biomedical Imaging, Yale Biomedical Imaging Institute, Magnetic Resonance Research Center, New Haven, CT, USA.
Anastasia CoppoliDepartment of Radiology and Biomedical Imaging, Yale Biomedical Imaging Institute, Magnetic Resonance Research Center, New Haven, CT, USA.
Kevin L BeharDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Barbara I GulanskiDepartment of Internal Medicine, Yale University, New Haven, CT, USA.
Brian PittmanDepartment of Psychiatry, Yale University, New Haven, CT, USA.
Stuart A WeinzimerDepartment of Internal Medicine, Yale University, New Haven, CT, USA.
Douglas L RothmanDepartment of Radiology and Biomedical Imaging, Yale Biomedical Imaging Institute, Magnetic Resonance Research Center, New Haven, CT, USA.
John H KrystalDepartment of Psychiatry, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-6952-1726
Graeme F MasonDepartment of Radiology and Biomedical Imaging, Yale Biomedical Imaging Institute, Magnetic Resonance Research Center, New Haven, CT, USA. graeme.mason@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Brain Acetate and Ethanol Metabolism in Alcohol Dependence and AbuseR01AA021984 · NIAAA · YALE UNIVERSITY · PI MASON, GRAEME F. · 2013 to 2017
$2.7M
Drinking, Brain Acetate, and StressR01AA031401 · NIAAA · YALE UNIVERSITY · PI Graeme F Mason · 2024 to 2026
$2.0M
Relationship of Brain Ethanol Oxidation with BehaviorR21AA028628 · NIAAA · YALE UNIVERSITY · PI MASON, GRAEME F. · 2020 to 2021
$440k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS R01 AA021984NIAAA NIH HHS R01 AA031401NIAAA NIH HHS R21 AA028628U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) TR001863U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA021984U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA028628U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA031401
6 · The paper itself

Abstract

Alcohol consumption elevates circulating acetate. Prior studies showed that acute alcohol reduces brain glucose uptake and increases brain acetate oxidation. Previously we showed that heavy drinkers have elevated capacity to oxidize brain acetate. Here we repeat the study, adding individuals with alcohol use disorder (AUD). Four groups were enrolled. The analysis data set included Light Drinkers (LD, n = 13, female = 5), at-risk Heavy Drinkers (HD, n = 15, female = 7), AUD patients in long-term recovery (≥6 months; AUD

Indexed as

AcetatesAlcohol DrinkingAlcoholismBrainAdultFemaleGlutamic AcidGlutamineHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedAcetatesGlutamic AcidGlutamine

Identifiers

PMID42218273
PMCPMC13334440

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.