Evidence map›Paper›PMID 42218126›Full record

ReviewNature communications2026

Beyond petrochemicals: challenges and opportunities in industrial-scale biomanufacturing.

Ji Yeon Kim, Hye Eun Yu, Min Ho Kim, Sang Yup Lee

Abstract readReview
In one paragraph

Review in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ji Yeon Kim *Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID 0000-0001-8040-0968
Hye Eun Yu *Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID 0000-0002-2493-1833
Min Ho KimMetabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.ORCID 0009-0004-6632-4101
Sang Yup LeeMetabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. leesy@kaist.ac.kr.ORCID 0000-0003-0599-3091

Funding

National Research Foundation of Korea (NRF) 2022M3J5A1056117National Research Foundation of Korea (NRF) RS-2024-00399424
6 · The paper itself

Abstract

Biomanufacturing offers a sustainable alternative to petrochemical manufacturing by harnessing engineered microorganisms to convert renewable feedstocks into diverse value-added products. Systems metabolic engineering has driven its advancement, enabling rational design of microbial strains with enhanced performance and robustness. Despite these achievements, large-scale commercialisation remains limited, highlighting the persistent gap between laboratory success and industrial deployment. We examine the challenges and opportunities in advancing biomanufacturing towards industrial implementation through two cases, succinic acid and polyhydroxyalkanoates, that exemplify products nearing, yet not fully reaching, commercial maturity. Finally, we discuss how integrating artificial intelligence with systems metabolic engineering can accelerate sustainable biomanufacturing.

Indexed as

Industrial MicrobiologyMetabolic EngineeringPolyhydroxyalkanoatesSuccinic AcidPolyhydroxyalkanoatesSuccinic Acid

Identifiers

PMID42218126
PMCPMC13222353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.