ArticleThe Journal of physiology2026
Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults.
Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Extreme makeover, heart edition: Determinants of exercise-induced cardiac remodelling in middle age.The Journal of physiology · 2026Article
- Exercise reverses the sedentary cardiac phenotype in obesity: a systematic review and meta-analysis of hemodynamic, structural, and functional adaptations.BMC sports science, medicine & rehabilitation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Sedentary ageing is linked to low cardiorespiratory fitness and the development of a small, stiff heart - risk factors for heart failure. Endurance exercise training reverses the effects of sedentary ageing on the heart when started in middle age; however, blunted training responses of females have been reported. Differences in baseline cardiac size or exercise-induced cardiac remodelling may underly sex differences in trainability. Therefore, we investigated whether sex and left ventricular end-diastolic volume indexed to body surface area (LV EDVi) influence the cardiovascular response to endurance training. Twenty-eight sedentary adults [15 females; age: 54 ± 5 years, peak oxygen uptake (
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Registered trials
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