Evidence map›Paper›PMID 42217562›Full record

ArticleCancer letters2026

NF1 loss in estrogen receptor-positive breast cancer induces osteoclast formation and immunosuppression to promote bone metastasis.

Zifan Zhao, Ze-Yi Zheng, Jonathan T Lei, Matthew J Baik, Yi-Hsuan Wu, Lauren K Somes, Andres F Mosquera Paternina, Omar A Harb, Owen A Chang, Fengshuo Liu and 12 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Zifan ZhaoLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Cancer & Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX, USA.
Ze-Yi ZhengLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Jonathan T LeiLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Matthew J BaikLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
Yi-Hsuan WuLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Cancer & Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX, USA.
Lauren K SomesLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Cancer & Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX, USA.
Andres F Mosquera PaterninaLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Omar A HarbLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
Owen A ChangDeBakey High School for Health Professions, Houston, TX, USA.
Fengshuo LiuLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
Matthew V HoltLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
Junkai WangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
Igor BadoTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hai WangMolecular and Cellular Biology Department, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
George MilesLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
Zbigniew GugalaDepartment of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch, Galveston, TX, USA.
Meenakshi AnuragLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Ahmed ElkhananyLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
Yi LiLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Valentina HoyosLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
Xiang H-F ZhangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Eric C ChangLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Electronic address: echang1@bcm.edu.

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Translational Research in Breast Cancer (SPORE)P50CA186784 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW J ELLIS · 2014 to 2026
$24.5M
CyTOF XT with Hyperion XTi platformS10OD036336 · OD · BAYLOR COLLEGE OF MEDICINE · PI BEETON, CHRISTINE · 2024 to 2024
$829k
BD FACSDiscover S8 Spectral and Imaging Cell SorterS10OD038251 · OD · BAYLOR COLLEGE OF MEDICINE · PI BEETON, CHRISTINE · 2025 to 2025
$563k
NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA186784NIH HHS S10 OD036336NIH HHS S10 OD038251
6 · The paper itself

Abstract

Estrogen receptor-positive (ER

Indexed as

Bone NeoplasmsBreast NeoplasmsNeurofibromin 1OsteoclastsReceptors, EstrogenAnimalsCell Line, TumorCoculture TechniquesFemaleGene Expression Regulation, NeoplasticHumansMiceNeurofibromin 1NF1 protein, humanReceptors, EstrogenAnd osteoporosisCytotoxicityEstrogen responseOsteogenesisRASSteroid hormone nuclear receptorT cell exhaustionT cell infiltrationTranscriptional co-repressor

Identifiers

PMID42217562
PMCPMC13418278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.