Evidence map›Paper›PMID 42217561›Full record

ArticleCancer letters2026

Ectopic integrin β1 overproduction by squamous carcinoma cells contributes to immune evasion-associated metastasis.

John D Aleman, Christian D Young, Yao Ke, Khoa A Nguyen, Ivan Lu, Jack B Goon, Anastasia E Abello, Hanne T Lind, Sana D Karam, Andrew C Birkeland and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

John D AlemanDepartment of Pathology, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA.
Christian D YoungDepartment of Pathology, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA.
Yao KeDepartment of Pathology & Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA, USA.
Khoa A NguyenDepartment of Pathology, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA.
Ivan LuDepartment of Pathology & Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA, USA.
Jack B GoonDepartment of Pathology & Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA, USA.
Anastasia E AbelloDepartment of Pathology & Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA, USA.
Hanne T LindDepartment of Pathology & Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA, USA.
Sana D KaramDepartment of Radiation Oncology, Washington University, Saint Louis, MO, USA.
Andrew C BirkelandDepartment of Otolaryngology-Head and Neck Surgery, University of California, Sacramento, CA, USA.
Xiao-Jing WangDepartment of Pathology, School of Medicine, University of Colorado Anschutz, Aurora, CO, USA; Department of Pathology & Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA, USA; Department of Otolaryngology-Head and Neck Surgery, University of California, Sacramento, CA, USA; VA Northern California Health Care System, Sacramento, CA, USA. Electronic address: drxwang@health.ucdavis.edu.

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
Treating recurrent HNSCC with radiation and dual TGF-Beta/PD-L1.P50CA261605 · NCI · UNIVERSITY OF COLORADO DENVER · PI LUCIA, M. SCOTT · 2021 to 2025
$10.1M
Assessing TGF Beta1-Mediated ECM Remodeling in Metastatic Oral Squamous Cell CarcinomaF31DE032592 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI ALEMAN, JOHN · 2022 to 2025
$134k
BLRD VA I01 BX003232BLRD VA IK6 BX006039NCI NIH HHS P30 CA046934NCI NIH HHS P30 CA093373NCI NIH HHS P50 CA261605NIDCR NIH HHS F31 DE032592
6 · The paper itself

Abstract

Distant metastasis often predicts poor survival for squamous cell carcinoma (SCC) patients. To identify potential targets for metastatic SCCs, we performed spatial profiling of SCC specimens from head and neck cancer patients to identify stage-associated markers. Laminin-binding integrins, normally restricted to basal keratinocytes, were enriched in Stage IV-A intratumoral regions vs Stage II/III SCCs, consistent with poor survival correlations of these integrins in TCGA. Due to the association of multiple laminin-binding integrins with poor prognosis, we assessed their collective impact on metastasis by knocking down integrin β1, a common partner of α-integrins, in mouse SCC cells derived from keratin 15 (K15)

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsIntegrin beta1Lung NeoplasmsTumor EscapeAnimalsCell Line, TumorFemaleHumansMiceNeoplasm MetastasisTumor MicroenvironmentIntegrin beta1Itgb1 protein, humanItgb1 protein, mouseCD8 T cellIntegrinLung metastasisSquamous cell carcinomaTumor microenvironment

Identifiers

PMID42217561
PMCPMC13428629

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.