Evidence map›Paper›PMID 42217309›Full record

ArticleContemporary clinical trials2026

Blueprint 2: A self-directed mobile adaptive coping skills intervention to improve psychological distress symptoms among cardiorespiratory failure survivors study protocol.

Robin L Baudier, Katie E Mosack, Jodi A Lapidus, Laura S Porter, Aliza Anderson, Aluko A Hope, Allison Johnson, Kristy Johnson, Kathryn Lesowski, Rafaela Avallone Mantelli and 12 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06538246 (Self-directed Mobile Adaptive Coping Skills Intervention to Improve Psychological Distress Symptoms Among Cardiorespiratory Failure Survivors), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06538246 narecruitingnot on this map

Self-directed Mobile Adaptive Coping Skills Intervention to Improve Psychological Distress Symptoms Among Cardiorespiratory Failure Survivors: Blueprint 2

TypeinterventionalSponsorDuke UniversityRan2024 to 2028Enrolled400ConditionsDepression, Anxiety, Post-traumatic Stress Disorder, StressArmsBlueprint, Education program
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Robin L BaudierBiostatistics and Design Program, Oregon Health & Science University, Portland, OR, USA; Oregon Health & Science University-Portland State University School of Public Health, Portland, OR, USA. Electronic address: baudier@ohsu.edu.
Katie E MosackOregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: mosack@ohsu.edu.
Jodi A LapidusBiostatistics and Design Program, Oregon Health & Science University, Portland, OR, USA; Oregon Health & Science University-Portland State University School of Public Health, Portland, OR, USA; Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: lapidusj@ohsu.edu.
Laura S PorterDepartment of Psychiatry & Behavioral Sciences, Duke University, Durham, NC, USA. Electronic address: Laura.Porter@duke.edu.
Aliza AndersonDepartment of Medicine, Division of Pulmonary, Allergy, & Critical Care Medicine, University of Colorado, Denver, CO, USA. Electronic address: aliza.anderson@cuanschutz.edu.
Aluko A HopeDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: hopeal@ohsu.edu.
Allison JohnsonDepartment of Medicine, Division of Pulmonary & Critical Care Medicine and the Program to Support People and Enhance Recovery (ProSPER), Duke University, Durham, NC, USA. Electronic address: allison.johnson@duke.edu.
Kristy JohnsonDepartment of Medicine, Division of Pulmonary & Critical Care Medicine and the Program to Support People and Enhance Recovery (ProSPER), Duke University, Durham, NC, USA. Electronic address: kristy.johnson@duke.edu.
Kathryn LesowskiOregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: lesowski@ohsu.edu.
Rafaela Avallone MantelliDepartment of Medicine, Division of Pulmonary, Allergy, & Critical Care Medicine, University of Colorado, Denver, CO, USA. Electronic address: rafaela.mantelli@cuanschutz.edu.
Carolyn J Marentes RuizDepartment of Medicine, Division of Pulmonary Critical Care, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: cmarentesruiz@mednet.ucla.edu.
Madeline McDougalDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: mcdoumad@ohsu.edu.
Luz Mejia-FloresDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: mejiaflo@ohsu.edu.
Julie MitchellOregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: mitcjuli@ohsu.edu.
Marc MossDepartment of Medicine, Division of Pulmonary, Allergy, & Critical Care Medicine, University of Colorado, Denver, CO, USA. Electronic address: Marc.moss@cuanschutz.edu.
Thanh H NevilleDepartment of Medicine, Division of Pulmonary Critical Care, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: TNeville@mednet.ucla.edu.
Cirila Estela Vasquez GuzmanDepartment of Family Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: vasquest@ohsu.edu.
Annette VuOregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: vua@ohsu.edu.
Edlyn L WolwowiczDepartment of Medicine, Oregon Health & Science University, Portland, OR, USA.
Catherine L HoughDepartment of Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: houghc@ohsu.edu.
Cynthia D MorrisOregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR, USA; Department of Medicine, Oregon Health & Science University, Portland, OR, USA. Electronic address: morrisc@ohsu.edu.
Christopher E CoxDepartment of Medicine, Division of Pulmonary & Critical Care Medicine and the Program to Support People and Enhance Recovery (ProSPER), Duke University, Durham, NC, USA. Electronic address: christopher.cox@duke.edu.

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
2/2 Self-directed mobile adaptive coping skills intervention to improve psychological distress symptoms among cardiorespiratory failure survivors: the Blueprint RCTU24HL168491 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Catherine Lee Hough, Cynthia D Morris · 2024 to 2026
$1.6M
1/2 Self-directed mobile adaptive coping skills intervention to improve psychological distress symptoms among cardiorespiratory failure survivors: the Blueprint RCTUG3HL168487 · NHLBI · DUKE UNIVERSITY · PI COX, CHRISTOPHER ETHAN · 2024 to 2024
$821k
NCATS NIH HHS UL1 TR002369NHLBI NIH HHS U24 HL168491NHLBI NIH HHS UG3 HL168487
6 · The paper itself

Abstract

introductionPersistent psychological distress including symptoms of depression, anxiety, and posttraumatic stress disorder (PTSD) occur in as many as 70% of intensive care unit (ICU) survivors. However, few therapies exist that target this population's unique symptoms and needs. To address this, we developed the Blueprint adaptive coping skills mobile app, which was found to be feasible and reduce psychological distress symptoms in a recent single-center pilot randomized control trial (RCT).

objectiveTo describe the methods of the Blueprint 2 multi-center RCT (clinicaltrials.gov ID NCT06538246) being conducted to test the efficacy of the Blueprint app in reducing psychological distress among ICU survivors compared to an education control in a geographically and sociodemographically diverse population, including Spanish-language speakers. METHODS AND ANALYSIS: In this RCT, 400 participants with a baseline Hospital Anxiety and Depression Scale (HADS) total score ≥ 8 will be randomized in a 1:1 ratio to intervention or control. The HADS total score at one month post-randomization is the primary outcome. Secondary outcomes include HADS anxiety and depression subscales, posttraumatic stress scale (PTSS), and the quality-of-life EQ-5D 100-point visual analog scale (VAS) at 1, 3, and 6 months. Select subgroup analyses including users of the Spanish-language version of the app will be used to evaluate consistency of effects across patient populations. Constrained longitudinal data analyses will compare outcomes across intervention groups and timepoints.

Indexed as

Coping SkillsHeart FailureMobile ApplicationsPsychological DistressStress, PsychologicalSurvivorsAnxietyDepressionHumansIntensive Care UnitsMulticenter Studies as TopicQuality of LifeRandomized Controlled Trials as TopicStress Disorders, Post-TraumaticAdaptive coping skills trainingAnxietyCritical illnessDepressionIntensive care unitsPsychological distress

Identifiers

PMID42217309
PMCPMC13475743

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