Evidence map›Paper›PMID 42217236›Full record

ArticleDiabetes & vascular disease research

Sex differences in cardiovascular disease risk in type 1 diabetes: The vascular bed paradox in women.

Abigayle B Simon, Dhruti Trivedi, Marsha Blackburn, Jeffrey Thomas, Matthew S Nicholson, Lawrence C Layman, Ryan A Harris

Abstract readComparative Study
In one paragraph

Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Comparing cutaneous NO-dependent vasodilation between young males and females.medRxiv : the preprint server for health sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abigayle B SimonGeorgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0002-7394-2088
Dhruti TrivediGeorgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Marsha BlackburnGeorgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Jeffrey ThomasGeorgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Matthew S NicholsonDepartment of Endocrinology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Lawrence C LaymanSection of Reproductive Endocrinology, Infertility, & Genetics, Department of Obstetrics & Gynecology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Ryan A HarrisGeorgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID 0000-0002-8826-681X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundCardiovascular disease (CVD) is the leading cause of death in individuals with type 1 diabetes (T1D). Epidemiological studies indicate that women with T1D are at greater risk of CVD compared to men with T1D. The present study sought to investigate differences in vascular health between men and women with T1D.Methods53 women with T1D and 25 men with T1D participated in this study. The flow-mediated dilation (FMD) test assessed endothelial-dependent conduit vessel function and nitroglycerin (NTG) was used to assess endothelial-independent vasodilation. In addition, cutaneous post-occlusive reactive hyperemia (PORH), local thermal heating (LTH), and iontophoresis of acetylcholine (ACH) were conducted to assess microvascular function, and pulse wave velocity (PWV) and pulse wave analysis (AIx75) were used as indices of arterial and aortic stiffness, respectively. Near-infrared spectroscopy was utilized to assess skeletal muscle oxidative capacity (SMOC).ResultsHemoglobin A

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 1Diabetic AngiopathiesEndothelium, VascularHealth Status DisparitiesVascular StiffnessVasodilationAdultCross-Sectional StudiesFemaleHeart Disease Risk FactorsHumansIontophoresisMaleMicrocirculationMiddle AgedNitroglycerinVasodilator Agentscardiovascular diseasesex differencestype 1 diabetesvascular function

Identifiers

PMID42217236
PMCPMC13222398

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.