Evidence map›Paper›PMID 42217186›Full record

ArticleCell reports2026

Enhancing the specificity of microglia genetic targeting using a CSF1R inhibitor.

Isaac W Babcock, Sydney A Labuzan, Abigail G Kelly, Anne E Schuster, Seblework Alemu, Lydia A Sibley, Anne E Marchildon, Tajie H Harris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isaac W BabcockCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Sydney A LabuzanCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Abigail G KellyCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Anne E SchusterCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Seblework AlemuCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Lydia A SibleyCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Anne E MarchildonCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Tajie H HarrisCenter for Brain Immunology and Glia, Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA. Electronic address: tajieharris@virginia.edu.

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
Biotechnology Training ProgramT32GM136615 · NIGMS · UNIVERSITY OF VIRGINIA · PI Silvia Salinas Blemker, Kimberly A. Kelly · 2020 to 2026
$3.4M
Alarmin-mediated control of CNS infectionR01NS112516 · NINDS · UNIVERSITY OF VIRGINIA · PI HARRIS, TAJIE H. · 2020 to 2023
$1.9M
Caspase-8 mediated control of CNS infectionR01NS134747 · NINDS · UNIVERSITY OF VIRGINIA · PI TAJIE H. HARRIS · 2024 to 2026
$1.5M
Brain, Immunology and Glia Training ProgramT32NS115657 · NINDS · UNIVERSITY OF VIRGINIA · PI Alban P Gaultier, TAJIE H. HARRIS · 2021 to 2026
$1.2M
NIAID NIH HHS T32 AI007046NIAID NIH HHS T32 AI007496NIGMS NIH HHS T32 GM136615NINDS NIH HHS R01 NS112516NINDS NIH HHS R01 NS134747NINDS NIH HHS T32 NS115657
6 · The paper itself

Abstract

Microglia are the resident macrophages of the brain and are central to neuroimmunology research. The roles of microglia are often probed by pharmacological depletion with CSF1R inhibitors or by genetic manipulation using Cre-lox systems, but microglia-specific genetic targeting remains challenging due to limited specificity or efficiency of Cre lines. We confirm that Cx3cr1

Indexed as

Gene TargetingMicrogliaReceptors, Granulocyte-Macrophage Colony-Stimulating FactorAnimalsBrainCX3C Chemokine Receptor 1IntegrasesMacrophagesMiceMice, Inbred C57BLOrganic ChemicalsTamoxifenCre recombinaseCsf1r protein, mouseCX3C Chemokine Receptor 1IntegrasesOrganic ChemicalsPLX5622Receptors, Granulocyte-Macrophage Colony-Stimulating FactorTamoxifenCP: immunologyCP: neurosciencegeneticsmicroglianeuroimmunologytissue-resident macrophages

Identifiers

PMID42217186
PMCPMC13359089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.