Observational studyJapanese journal of ophthalmology2026
Comparison of one-year postoperative outcomes between PreserFlo MicroShunt and trabeculectomy in Japanese patients with open angle glaucoma: a retrospective cohort study using propensity score matching.
Observational study in Japanese journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
purposeTo compare one‑year postoperative outcomes between PreserFlo MicroShunt (PMS) and trabeculectomy (TLE) as primary filtration surgery in Japanese patients with open‑angle glaucoma using propensity score matching. STUDY
designRetrospective, single‑center observational cohort study.
methodsPatients with open‑angle glaucoma who underwent stand‑alone PMS implantation or TLE at Kobe University Hospital were included. After applying exclusion criteria, 102 eyes in each of 2 groups were matched 1:1 using propensity scores based on age, sex, lens status, glaucoma subtype, preoperative intraocular pressure (IOP), number of glaucoma medications, and best‑corrected visual acuity (BCVA). The primary outcome was IOP at 12 months postoperatively. Secondary outcomes included longitudinal IOP changes, medication use, BCVA, corneal endothelial cell density (ECD), surgical success rates, postoperative complications, and additional surgery. Mixed‑effects models and Kaplan-Meier analyses were performed.
resultsAt 12 months, mean IOP was significantly lower in the TLE group than in the PMS group (12.3 vs 14.1 mmHg, P = 0.042). Both groups showed significant IOP reduction from baseline. The proportion of medication‑free eyes did not differ between groups. BCVA worsened transiently after surgery and partially recovered but remained worse than baseline at 12 months, with no between‑group differences. ECD decreased modestly in both groups without significant differences. Surgical success rates were comparable across all criteria. Postoperative complications, particularly hypotony‑related events, were more frequent in the TLE group, and persistent hypotony was observed only after TLE.
conclusionsPMS demonstrated a more favorable safety profile with fewer hypotony‑related complications, whereas TLE achieved greater IOP reduction at 12 months. Surgical success rates were comparable. PMS may represent a less invasive option, while TLE may be preferable when maximal IOP lowering is required.
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