Evidence map›Paper›PMID 42217127›Full record

ArticleJournal of bioenergetics and biomembranes2026

The FOXO3/ZC3H13/SLC3A2 cascade modulates the osteogenic differentiation and ferroptosis of BMSCs.

Weifu He, Xiaoyan Shi, Zhengquan Dong, Wenjun Zhang, Lijun Cai, Zhenye Guo, Zhi Lv

Abstract read
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In one paragraph

Article in Journal of bioenergetics and biomembranes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Weifu He *Department of Orthopaedics, the Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan City, Shanxi Province, China.
Xiaoyan Shi *Department of Orthopaedics, the Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan City, Shanxi Province, China.
Zhengquan DongDepartment of Orthopaedics, the Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan City, Shanxi Province, China.
Wenjun ZhangDepartment of Pharmacy, The Second Hospital of Shanxi Medical University, Taiyuan City, Shanxi, 030001, China.
Lijun CaiDepartment of Clinical Laboratory, The Second Hospital of Shanxi Medical University, Taiyuan City, Shanxi, 030001, China.
Zhenye GuoDepartment of Orthopaedics, the Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan City, Shanxi Province, China. GZY2025SCI@163.com.
Zhi LvDepartment of Orthopaedics, the Second Hospital of Shanxi Medical University, No. 382, Wuyi Road, Xinghualing District, Taiyuan City, Shanxi Province, China. 13653653329@139.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired osteogenic differentiation in bone marrow-derived mesenchymal stem cells (BMSCs) is involved in the pathogenesis of osteoporosis. ZC3H13, a crucial m6A writer, promotes BMSC osteogenic differentiation by inhibiting ferroptosis. However, its molecular underpinnings remain largely unexplored. Expression analysis was performed by quantitative PCR and immunoblotting. Cell proliferation was assessed by EdU assay. Osteogenic differentiation was assessed using alkaline phosphatase (ALP) expression/activity assays and Alizarin Red staining. Ferroptosis alteration was evaluated by detecting ROS, Fe

Indexed as

FerroptosisForkhead Box Protein O3Mesenchymal Stem CellsOsteogenesisAnimalsCell DifferentiationHumansForkhead Box Protein O3FOXO3 protein, humanBone marrow-derived mesenchymal stem cellsFerroptosisFOXO3/ZC3H13/SLC3A2 axisOsteogenic differentiationOsteoporosis

Identifiers

PMID42217127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.