Evidence map›Paper›PMID 42217015›Full record

ArticleInternational urogynecology journal2026

MRI 2-D Parameters Associated with Native Tissue or Transvaginal Mesh Surgical Apical Prolapse Repair Failure.

Mark E Lockhart, Pamela A Moalli, Holly E Richter, Isuzu Meyer, Allison C Weidner, Yuko M Komesu, Benjamin Carper, Marie G Gantz, Eunice Kennedy Shriver NICHD Pelvic Floor Disorders Network

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International urogynecology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01802281 (A Randomized Trial of Vaginal Surgery for Uterovaginal Prolapse), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01802281 nacompletednot on this map

A Randomized Trial of Vaginal Surgery for Uterovaginal Prolapse: Vaginal Hysterectomy With Native Tissue Vault Suspension vs. Mesh Hysteropexy Suspension

TypeinterventionalSponsorNICHD Pelvic Floor Disorders NetworkRan2013 to 2025Enrolled183ConditionsUterovaginal ProlapseArmsUterosacral ligament suspension, Uphold® LITE
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mark E LockhartDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Pamela A MoalliDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Division of Urogynecology and Reconstructive Pelvic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Holly E RichterDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, 619 19th Street South, Birmingham, AL, 35243, USA. hrichter@uabmc.edu.ORCID http://orcid.org/0000-0001-7741-5771
Isuzu MeyerDepartment of Obstetrics and Gynecology, University of Alabama at Birmingham, 619 19th Street South, Birmingham, AL, 35243, USA.
Allison C WeidnerDepartment of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA.
Yuko M KomesuDepartment of Obstetrics and Gynecology, University of New Mexico, Albuquerque, NM, USA.
Benjamin CarperSocial, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC, USA.
Marie G GantzSocial, Statistical, and Environmental Sciences, RTI International, Research Triangle Park, NC, USA.
Eunice Kennedy Shriver NICHD Pelvic Floor Disorders Network

Funding

Pelvic Floor Disorders Network Data Coordinating Center (U01)U01HD069031 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI GANTZ, MARIE G · 2011 to 2015
$19.7M
Perioperative Pelvic Floor Rehab: A Rrandomized TrialU10HD041261 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RICHTER, HOLLY E · 2001 to 2015
$5.1M
UNC Pelvic Floor Disorders Research CollaborativeU10HD041267 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VISCO, ANTHONY G · 2001 to 2015
$5.0M
Training in Biomechanics in Regenerative MedicineT32EB003392 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WOO, SAVIO L-Y. · 2005 to 2020
$4.0M
Pelvic Floor Disorders NetworkU10HD054214 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LUKACZ, EMILY S. · 2006 to 2015
$3.3M
The Cleveland Clinic Clinical SiteU10HD054215 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI BARBER, MATTHEW D · 2006 to 2015
$3.2M
Pelvic Floor Disorders Network Clinical Sites (U10)U10HD069010 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI ARYA, LILY A · 2011 to 2015
$1.7M
Brown/WIH Pelvic Floor Disorders Network SiteU10HD069013 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI SUNG, VIVIAN W · 2011 to 2015
$1.6M
Pittsburgh Pelvic Floor Research ProgramU10HD069006 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI ZYCZYNSKI, HALINA M · 2011 to 2015
$1.6M
RCT of Hypnotherapy vs Tpolterodine for OAB: Voiding and Brain Activation ChangesU10HD069025 · NICHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ROGERS, REBECCA GLENN · 2011 to 2015
$1.6M
NIBIB NIH HHS T32 EB003392NICHD NIH HHS U01 HD069031NICHD NIH HHS U10 HD041261NICHD NIH HHS U10 HD041267NICHD NIH HHS U10 HD054214NICHD NIH HHS U10 HD054215NICHD NIH HHS U10 HD069006NICHD NIH HHS U10 HD069010NICHD NIH HHS U10 HD069013NICHD NIH HHS U10 HD069025
6 · The paper itself

Abstract

introduction and hypothesisMagnetic resonance imaging (MRI) can evaluate individual components of postsurgical recurrent prolapse that may not be visible on physical examination and provide insights into mechanisms of prolapse recurrence.

methodsThis planned prospective secondary imaging analysis at nine clinical sites performed in the Study of Uterine Prolapse Procedures-Randomized (SUPeR) trial of the National Institute of Child Health & Human Development (NICHD) Pelvic Floor Disorders Network (ClinicalTrials.gov: NCT01802281) randomized 183 women to native tissue repair (NTR-hysterectomy) or vaginal mesh repair (VM-hysteropexy) for uterovaginal prolapse, and assessed for surgical failure. A subset of participants who enrolled in Defining Mechanisms of Anterior Vaginal Wall Descent (DEMAND) underwent MRI at rest, maximal strain, and post-strain rest (recovery) 30-42 months after surgery or prior to 30 months if undergoing reoperation for recurrence.

resultsOf the 88 participants analyzed (aged 65 ± 7.7 years), 22 (25.0%) had surgical failure by clinical criteria, 8/45 (17.8%) VM-hysteropexy; 14/43 (32.6%) NTR-hysterectomy, p = 0.14. Larger genital hiatus (H-line, 86.5 mm vs 72.3 mm, p = 0.003), low posterior position during strain (M-line, 55.6 mm vs 40.3 mm, p = 0.005), and apical compartments (vaginal apex position below pubococcygeal line (PCL), 42.1 mm vs 13.1 mm, p < 0.001) were associated with failure vs success after VM-hysteropexy. In the NTR-hysterectomy group, failures demonstrated greater vaginal width (46.3 mm vs 41.3 mm, p = 0.04), vaginal circumference (108.5 mm vs 96.1 mm, p = 0.03), and bladder descent vs successes.

conclusionsPelvic MRI parameters associated with surgical failure vs success varied between VM-hysteropexy and vaginal hysterectomy.

Indexed as

2-D MRINative tissue vaginal hysterectomyPelvic organ prolapseProlapse surgeryTransvaginal mesh hysteropexy

Identifiers

PMID42217015
PMCPMC13426472

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Registered trials

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