ArticleJournal of materials science. Materials in medicine2026
Antibacterial and osteogenic effect of EGCG/HAP/AgNPs composite coating on titanium surface.
Article in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Titanium implants are widely used in dental applications; however, their clinical application is still limited by challenges such as bacterial infection and poor osseointegration. In this study, a composite coating consisting of epigallocatechin-3-gallate (EGCG), hydroxyapatite (HAP), and silver nanoparticles (AgNPs) was fabricated on the titanium surface to improve its antibacterial activity and osteogenic potential. The coating was prepared via alkali-thermal treatment, followed by EGCG adhesion and subsequent deposition of HAP and AgNPs. Surface characterization confirmed successful construction of the coating with improved hydrophilicity. The EGCG/HAP/AgNPs coating showed gradual changes in surface morphology and elemental composition after PBS immersion, suggesting partial coating degradation while retaining detectable residual Ag, Ca, and P on the titanium surface. The coating also exhibited effective antibacterial activity against Staphylococcus aureus and significantly promoted osteogenic differentiation of MC3T3-E1 cells, as evidenced by enhanced alkaline phosphatase activity and mineralized nodule formation. These results demonstrate that the EGCG/HAP/AgNPs composite coating possesses good antibacterial capacity, osteogenic activity, and biocompatibility, showing great potential for improving the clinical performance of titanium implants.
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