Evidence map›Paper›PMID 42216943›Full record

ArticleJACC. Case reports2026

Multimodality Cardiac Imaging and Multidisciplinary Collaboration in Monitoring Intracardiac Sarcoma Response to Immunotherapy.

Christopher Kocx, Lucy Geraghty, Zara Rolfe, Hayden McColl, Cameron Holloway, Vivek Bhadri, Sameer Karve, Jia Liu, Imre Hunyor

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher KocxDepartment of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. Electronic address: christopher.kocx@sydney.edu.au.
Lucy GeraghtyDepartment of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Zara RolfeDepartment of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Hayden McCollDepartment of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Cameron HollowayDepartment of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia; Faculty of Medicine and Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Vivek BhadriDepartment of Medical Oncology, Chris O'Brien Lifehouse, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Sameer KarveDepartment of Cardiology, Orange Base Hospital, Orange, New South Wales, Australia.
Jia LiuFaculty of Medicine and Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia; The Kinghorn Cancer Centre, St Vincent's Hospital, Sydney, New South Wales, Australia; Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
Imre HunyorDepartment of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntracardiac metastases causing right ventricular outflow tract obstruction are rare and carry a dismal prognosis. Immune checkpoint inhibitor (ICI) therapy risks immune-mediated pseudoprogression that could worsen hemodynamic obstruction. CASE SUMMARY: A 40-year-old man with metastatic alveolar soft part sarcoma presented with dyspnea, pericardial effusion, and intracardiac masses causing significant right ventricular outflow tract obstruction. Cardiac magnetic resonance tissue characterization established a noninvasive diagnosis without endomyocardial biopsy. ICI therapy was delivered as an inpatient in a coronary care unit with continuous cardiology monitoring. Serial echocardiography demonstrated progressive reduction in mass size with relief of obstruction, and Cardiac magnetic resonance confirmed treatment response. More than 2 years later, he achieved complete metabolic response on positron emission tomography-computed tomography and remains well in active surveillance. DISCUSSION: Multimodality imaging provides complementary hemodynamic, tissue-level, and metabolic surveillance essential for detecting pseudoprogression and confirming true treatment response in hemodynamically significant intracardiac tumors. TAKE-HOME MESSAGE: Multidisciplinary cardio-oncology collaboration can enable safe ICI delivery and durable complete response in hemodynamically significant intracardiac metastatic disease.

Indexed as

alveolar soft part sarcomacardiac magnetic resonancecardio-oncologyimmunotherapyintracardiac metastasisright ventricular outflow tract obstruction

Identifiers

PMID42216943
PMCPMC13420687

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