ArticleAngewandte Chemie (International ed. in English)2026
γ-Ray Regulated Host-Guest Molecular Recognition.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Decades of advances in light-responsive host-guest supramolecular systems allow precise molecular switching and photoactivation, yet their in vivo use is severely limited by the weak tissue penetration of UV/visible light. Ionizing radiation such as γ-rays possesses outstanding deep-tissue penetration, which has been widely applied in clinical radiology and radiotherapy. Herein, we develop a γ-irradiation-regulated host-guest recognition system based on azobenzene derivatives and macrocyclic hosts (cyclodextrins and cucurbiturils). At a clinical dose of 2 Gy, γ-radiation triggers cis-to-trans isomerization of azobenzene and enables efficient molecular recognition with macrocycles. γ-Rays outperform blue light in inducing isomerization even through centimeter-thick porcine tissues, and the system exhibits excellent recyclability over ten irradiation cycles. Moreover, γ-ray-regulated ternary recognition realizes in situ hydrogelation, constructing double-network hydrogels with simultaneous mechanical reinforcement, stiffening and self-healing. The hydrogel achieves tensile strength of ∼23 MPa and toughness of ∼30 MJ m
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