Evidence map›Paper›PMID 42216768›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

DNA Framework Nucleator-Enabled Intelligent Hydrogel Interfaces on Living Cells.

Yuxuan Wu, Yuanhao Wang, Jingrui Yang, Yueyue Feng, Zhiyuan Liu, Wanting Jin, Shuangye Zhang, Shihua Luo, Chunhai Fan, Fei Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuxuan WuDepartment of Liver Surgery, School of Medicine, Shanghai Institute of Transplantation, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0009-0003-7903-3672
Yuanhao WangDepartment of Liver Surgery, School of Medicine, Shanghai Institute of Transplantation, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jingrui YangDepartment of Liver Surgery, School of Medicine, Shanghai Institute of Transplantation, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Yueyue FengState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center For Transformative Molecules, Zhang Jiang Institute For Advanced Study and National Center For Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhiyuan LiuState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center For Transformative Molecules, Zhang Jiang Institute For Advanced Study and National Center For Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wanting JinState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center For Transformative Molecules, Zhang Jiang Institute For Advanced Study and National Center For Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shuangye ZhangDepartment of Chemistry, The Chinese University of Hong Kong, Hong Kong, China.
Shihua LuoDepartment of Traumatology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Chunhai FanState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center For Transformative Molecules, Zhang Jiang Institute For Advanced Study and National Center For Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-7171-7338
Fei WangState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center For Transformative Molecules, Zhang Jiang Institute For Advanced Study and National Center For Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xiaolei ZuoInstitute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0001-7505-2727
Hao FengDepartment of Liver Surgery, School of Medicine, Shanghai Institute of Transplantation, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Qian LiState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center For Transformative Molecules, Zhang Jiang Institute For Advanced Study and National Center For Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0002-1166-6583
Qiang XiaDepartment of Liver Surgery, School of Medicine, Shanghai Institute of Transplantation, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
Fei DingDepartment of Liver Surgery, School of Medicine, Shanghai Institute of Transplantation, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0003-2340-5644

Funding

National Key Research and Development Program of China 2023YFB3208200National Natural Science Foundation of China 22322704State Key Program of National Natural Science Foundation of China 82241221
6 · The paper itself

Abstract

Engineering intelligent interfaces on living cells is essential for precise cellular manipulation. Here, we developed a DNA framework nucleator (DFN)-guided strategy for the controlled assembly of high-fidelity stimuli-responsive intelligent hydrogel interfaces (HIs) on living cell surfaces. Using a rigid tetrahedral DNA framework as the structural core, DFNs served as stable and ordered nucleation sites on the cell membrane, which directed localized branched hybridization chain reaction to form single-cell HIs. For ATP-responsive HIs, a response efficiency of ∼90.7% was achieved, representing an ∼2.9-fold enhancement over the HIs guided by a flexible double-stranded DNA nucleator (dsDN). Notably, this platform supports the integration of dual-locked and crosstalk-free logic gate function, triggering efficient disassembly exclusively when both ATP and microRNA-122 are present. This AND-gate function yielded a response efficiency of ∼98.5%, outperforming the dsDN-guided control by 4.2-fold, with a background crosstalk below ∼4.0%. These results demonstrate that ordered nucleation is essential for high-fidelity signal processing at cellular interfaces, advancing the field from static encapsulation to dynamic, logic-regulated systems and establishing a versatile platform for next-generation programmable cell-based applications.

Indexed as

DNAHydrogel, Polyethylene Glycol DimethacrylateHydrogelsAdenosine TriphosphateDNA NanostructuresHumansAdenosine TriphosphateDNAHydrogel, Polyethylene Glycol DimethacrylateHydrogelscell membrane engineeringDNA hydrogelDNA nanotechnologyhybridization chain reactiontetrahedral DNA framework

Identifiers

PMID42216768
PMCPMC13392786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.