Evidence map›Paper›PMID 42216567›Full record

ArticleOncoimmunology2026

Umbilical cord blood natural killer cells improve anti-GD2 antibody efficacy in neuroblastoma: from mouse to human.

Mengjia Song, Yingxia Lan, Xiya Tan, Linnan Wu, Jia Zhu, Suying Lu, Feifei Sun, Min Gao, Junting Huang, Yi Que and 7 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Mengjia SongCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yingxia LanCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xiya TanCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Linnan WuCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Jia ZhuCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Suying LuCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Feifei SunCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Min GaoCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Junting HuangCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yi QueCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yu ZhangCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Xiaona FangCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Mengzhen LiCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yumiao MaiCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Juan WangCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Tong XiangCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Yizhuo ZhangCollaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.ORCID 0000-0002-6128-3476

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite advances in anti-disialoganglioside (GD2) immunotherapy, high-risk neuroblastoma (NB) remains a clinical challenge. Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity is a potent mechanism of action of anti-GD2 antibody. However, dose-intensive chemotherapy causes NK cell depletion. Here, a positive association between intratumoral NK cell infiltration and anti-GD2 efficacy was first observed in clinical samples. We then established the unique advantages of

Indexed as

Fetal BloodGangliosidesKiller Cells, NaturalNeuroblastomaAnimalsCell Line, TumorFemaleHumansImmunotherapyMaleMiceTumor MicroenvironmentXenograft Model Antitumor Assaysganglioside, GD2Gangliosidesanti-GD2 therapycombined immunotherapyNeuroblastomatumor microenvironmentumbilical cord blood natural killer cells

Identifiers

PMID42216567
PMCPMC13224756

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.