Evidence map›Paper›PMID 42216495›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2026

Pubertal Timing Associates With Cardiometabolic Markers During Puberty and in Young Adulthood.

Saga Nummela, Katja Pahkala, Sinikka Karppinen, Jorma Toppari, Olli Raitakari, Jorma Viikari, Tapani Rönnemaa, Harri Niinikoski

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Article in Acta paediatrica (Oslo, Norway : 1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Saga NummelaUniversity of Turku, Turku, Finland.ORCID https://orcid.org/0000-0002-6379-910X
Katja PahkalaCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Sinikka KarppinenDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Jorma ToppariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.ORCID https://orcid.org/0000-0003-2228-334X
Olli RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Jorma ViikariDivision of Medicine, Turku University Hospital, Turku, Finland.
Tapani RönnemaaDivision of Medicine, Department of Medicine, Turku University Hospital, University of Turku, Turku, Finland.
Harri NiinikoskiCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

Funding

Academy of Finland 206374Academy of Finland 251360Academy of Finland 275595Academy of Finland 294834Academy of Finland 307996Academy of Finland 322112Finnish Foundation of Cardiovascular ResearchFinnish Ministry of Education and CultureJuho Vainion SäätiöSigrid Juséliuksen SäätiöSpecial Governmental Grants for Health Sciences ResearchSuomen KulttuurirahastoThe Finnish Medical FoundationTurun YliopistosäätiöYrjö Jahnssonin Säätiö
6 · The paper itself

Abstract

aimTo study how pubertal timing associates with cardiometabolic measures in puberty and young adulthood.

methodsCardiovascular risk factors, anthropometry and pubertal development were regularly studied in STRIP study subjects until age 26 years. The study participants were divided into tertiles (early, average, and late) according to the age at the beginning of breast/testicular growth, menarche in females, and end of testicular growth in males. Differences in cardiometabolic variables between tertiles were analysed using one-way ANOVA.

resultsEarlier breast development was associated with higher body mass index (BMI), waist circumference (WC), and blood pressure (BP) in adulthood compared to the late group. Earlier age at menarche was associated with higher BMI and WC in adulthood. Earlier beginning of testicular enlargement was associated with higher insulin and insulin resistance at 26 years when compared to the late group. Earlier end of testicular growth tended to have higher insulin values and insulin resistance at 26 years than the average group.

conclusionsEarly pubertal development in females is associated with higher BMI and WC. In males, early pubertal development is associated with increased insulin levels and insulin resistance. More research is needed to study whether these metabolic differences build up a cumulative burden.

Indexed as

Cardiometabolic Risk FactorsPubertyAdolescentAdultBiomarkersBlood PressureBody Mass IndexChildFemaleHumansMaleWaist CircumferenceYoung AdultBiomarkersblood pressurebody mass indexcardiometabolic healthpubertyserum lipids

Identifiers

PMID42216495
PMCPMC13552584

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