Evidence map›Paper›PMID 42216479›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes.

Tenielle Porter, Ayeisha Milligan Armstrong, Eleanor K O'Brien, Vincent Doré, Pierrick Bourgeat, Mitchell Turner, Paul Maruff, Christopher C Rowe, Belinda M Brown, Victor L Villemagne and 3 more

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tenielle PorterCentre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia.
Ayeisha Milligan ArmstrongCentre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia.
Eleanor K O'BrienCentre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia.
Vincent DoréCentre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia.
Pierrick BourgeatAustralian E-Health Research Centre, CSIRO, Herston, Queensland, Australia.
Mitchell TurnerCentre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia.
Paul MaruffFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Christopher C RoweDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia.
Belinda M BrownCentre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia.
Victor L VillemagneCentre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia.
Stephanie R Rainey-SmithSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Simon M LawsCentre for Precision Health, Edith Cowan University, Joondalup, Western Australia, Australia.ORCID https://orcid.org/0000-0002-4355-7082
AIBL Research Group

Funding

Alzheimer's Association (USA)Alzheimer's Drug Discovery FoundationNHMRC Investigator GNT1197315the NHMRC GNT1161706the NHMRC GNT2001320
6 · The paper itself

Abstract

introductionVariants in the aquaporin-4 gene (AQP4) have been associated with Alzheimer's disease (AD) diagnosis, cognition, and brain amyloid beta (Aβ) and may affect the sleep and Aβ relationship. Their association with other AD-related phenotypes/disease progression remain largely unknown.

methodsAssociations between AQP4 variants, self-reported sleep measures, and AD-related phenotypes in cognitively unimpaired individuals with evidence of Aβ accumulation were examined using data from the Australian Imaging, Biomarkers and Lifestyle study.

resultsAQP4 variants were directly associated with regional brain volumes, atrophy, and cognition. They were also associated with differences in regional brain volumes and atrophy in interaction with sleep duration, latency, and quality. Finally, AQP4 variants were associated with cognitive decline in interaction with sleep disturbances. DISCUSSION: These findings support a relationship between AQP4 and AD phenotypes, both directly and through their interaction with sleep.

Indexed as

Alzheimer DiseaseAquaporin 4SleepSleep Wake DisordersAgedAmyloid beta-PeptidesAtrophyAustraliaBrainFemaleGenetic VariationHumansMagnetic Resonance ImagingMalePhenotypeAmyloid beta-PeptidesAQP4 protein, humanAquaporin 4Amyloid betaaquaporin‐4 (AQP4)brain volumecognitionglymphatic systemsleep

Identifiers

PMID42216479
PMCPMC13239059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.