ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026
A Bio-Based Chiroptical Overcrowded Alkene From Flavanone: Photoreactivity and Theoretical Investigation.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Bio-Based Chiroptical Overcrowded Alkene From Flavanone: Photoreactivity and Theoretical Investigation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The design of light-driven overcrowded alkenes often relies on complex synthetic strategies to achieve precise control over rotational motion. In this study, we demonstrate a sustainable approach to design an overcrowded alkene and an O-heterocyclic phenanthrene derivative using a bio-based enantiopure flavanone, (-)-isolonchocarpin, as starting material. The synthesis involves a McMurry deoxygenative homocoupling reaction to generate a sterically hindered overcrowded alkene, which can further undergo photochemical (E/Z)-isomerization and oxidative 6π-electrocyclization. The oxidation product was shown to have emission properties, highlighting the potential of synthesizing bio-based chromophoric compounds in minimal steps. Computational studies using spin-flip time-dependent density functional theory (SF-TDDFT) reveal that the inherent chirality of the starting material induces asymmetry in the rotational pathway, biasing the directionality of motion. By integrating enantiopure natural products into functional photoresponsive materials, this work offers a more sustainable route to develop new bio-based photoresponsive molecular machines while deepening our understanding of chirality-driven motion in dynamic systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.