ArticleJournal of the American Heart Association2026
Medial Neovascularization: A Novel Mechanism of Aortic Dissection in a Hypertensive Population?
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to elucidate the impact of vasa vasorum on the natural progression of aortic dissection in patients with hypertension.
methodsFull-thickness ascending aortic walls from 43 participants (median age, 53 years; 32.6% women) were analyzed using pathological observation and shear stress measurement. Comparisons among hypertensive dissection (AD, n=23), hypertensive control (n=12), and nonhypertensive dissection (non-HT-AD, n=8) groups were performed using Kruskal-Wallis and repeated-measures ANOVA tests.
resultsCompared with the control group, a higher density of vasa vasorum was observed within the outer third of the tunica media (medial neovascularization [MN]) in the AD group (adjusted
conclusionsMN and subsequent vasa vasorum rupture in the outer tunica media may represent an alternative initiating event in hypertension-related aortic dissection, distinct from the classical intimal tear. However, the cross-sectional nature of this study precludes definitive causal conclusions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.