Evidence map›Paper›PMID 42216238›Full record

Observational studyClinical pharmacology and therapeutics2026

Piperacillin Population Pharmacokinetics in Plasma and Peritoneal Fluid and Dosing Optimization in Children Undergoing Liver Transplant: An Optimome Study.

Noémie de Cacqueray, Mehdi Oualha, Frantz Foissac, Leo Froelicher Bournaud, Gabrielle Lui, Emmanuelle Bille, Christophe Chardot, Carmen Capito, Florence Lacaille, Philippine Widmer and 5 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Noémie de CacquerayService Réanimation et Soins Intensifs Polyvalents Pédiatriques - SMUR pédiatrique, AP-HP, Hôpital Necker Enfants Malades, Paris, France.ORCID 0009-0002-4280-4683
Mehdi OualhaService Réanimation et Soins Intensifs Polyvalents Pédiatriques - SMUR pédiatrique, AP-HP, Hôpital Necker Enfants Malades, Paris, France.ORCID 0000-0002-0488-5948
Frantz FoissacUniversité Paris Cité, Inserm, UMR1343, Pharmacologie et Évaluations des Thérapeutiques Chez l'Enfant et la Femme Enceinte, Paris, France.ORCID 0009-0001-3950-7728
Leo Froelicher BournaudUniversité Paris Cité, Inserm, UMR1343, Pharmacologie et Évaluations des Thérapeutiques Chez l'Enfant et la Femme Enceinte, Paris, France.
Gabrielle LuiUniversité Paris Cité, Inserm, UMR1343, Pharmacologie et Évaluations des Thérapeutiques Chez l'Enfant et la Femme Enceinte, Paris, France.ORCID 0000-0002-6529-0024
Emmanuelle BilleService Microbiologie, AP-HP, Hôpital Necker Enfants Malades, Paris, France.
Christophe ChardotService Chirurgie pédiatrique, Transplantation, AP-HP, Hôpital Necker Enfants Malades, Paris, France.
Carmen CapitoService Chirurgie pédiatrique, Transplantation, AP-HP, Hôpital Necker Enfants Malades, Paris, France.ORCID 0000-0001-5791-5402
Florence LacailleService Gastroentérologie-Nutrition pédiatriques et Unité d'Hépatologie Transplantation Pédiatrique, AP-HP, Hôpital Necker Enfants Malades, Paris, France.
Philippine WidmerService Réanimation et Soins Intensifs Polyvalents Pédiatriques - SMUR pédiatrique, AP-HP, Hôpital Necker Enfants Malades, Paris, France.
Julie ToubianaService Pédiatrie Générale et Maladies Infectieuses, AP-HP, Hôpital Necker Enfants Malades, Paris, France.
Jean Marc TréluyerUniversité Paris Cité, Inserm, UMR1343, Pharmacologie et Évaluations des Thérapeutiques Chez l'Enfant et la Femme Enceinte, Paris, France.
Sihem BenaboudUniversité Paris Cité, Inserm, UMR1343, Pharmacologie et Évaluations des Thérapeutiques Chez l'Enfant et la Femme Enceinte, Paris, France.
Naïm BouazzaUniversité Paris Cité, Inserm, UMR1343, Pharmacologie et Évaluations des Thérapeutiques Chez l'Enfant et la Femme Enceinte, Paris, France.
Agathe BérangerService Réanimation et Soins Intensifs Polyvalents Pédiatriques - SMUR pédiatrique, AP-HP, Hôpital Necker Enfants Malades, Paris, France.ORCID 0000-0002-9751-8249

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Piperacillin-tazobactam is frequently used in children undergoing liver transplantation (LT), yet its pharmacokinetics (PK) in this population remains poorly characterized. We aimed to develop a population pharmacokinetic model for piperacillin in plasma and peritoneal fluid in children undergoing LT and to optimize dosing regimen for this population. We conducted a retrospective, single-center, observational study including all children receiving piperacillin-tazobactam as prophylaxis for LT and had at least one piperacillin concentration in both plasma and peritoneal fluid. PK analysis was conducted using nonlinear mixed effect modeling (Monolix) and was part of Optimome study. We included 31 patients with a median (range) age of 4 years (4 months-17 years). A total of 172 plasma and 146 peritoneal fluid samples were analyzed. Plasma concentrations were best fitted by a one-compartment model with first-order elimination. A virtual effect site compartment was added to adequately describe piperacillin concentrations in plasma and peritoneal fluid. Allometrically scaled body weight (pre-transplant and current values) and glomerular filtration rate (eGFR) were identified as significant covariates. Median (range) peritoneal/plasma AUC

Indexed as

Anti-Bacterial AgentsAscitic FluidLiver TransplantationModels, BiologicalPiperacillinPiperacillin, Tazobactam Drug CombinationAdolescentAntibiotic ProphylaxisArea Under CurveChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesAnti-Bacterial AgentsPiperacillinPiperacillin, Tazobactam Drug Combination

Identifiers

PMID42216238
PMCPMC13339453

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.