Evidence map›Paper›PMID 42216076›Full record

ArticleActa neuropathologica communications2026

ATM-kinase deficiency triggers early multi-compartment remodeling of the cerebellar microenvironment.

Francesca Montarolo, Luna Berrino, Anita Maria Rominto, Matilde Loddo, Ilaria Balbo, Anastasia Ricci, Giulia Pia Servetto, Ginevra Mango, Kenta Yamamoto, Roberta Parolisi and 6 more

Abstract read
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In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Francesca MontaroloDepartment of Neuroscience, University of Torino, Via Cherasco 15, 10125, Torino, Italy.
Luna BerrinoDepartment of Neuroscience, University of Torino, Via Cherasco 15, 10125, Torino, Italy.
Anita Maria RomintoDepartment of Neuroscience, University of Torino, Via Cherasco 15, 10125, Torino, Italy.
Matilde LoddoNeuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, 10043, Orbassano, TO, Italy.
Ilaria BalboDepartment of Neurology, College of Physicians and Surgeons, Columbia University, 10032, New York, NY, USA.
Anastasia RicciDepartment of Biomolecular Sciences, University of Urbino "Carlo Bo" Campus Scientifico Enrico Mattei, Via Cà le Suore, 2, 61029, Urbino, PU, Italy.
Giulia Pia ServettoDepartment of Earth Sciences, University of Torino, via Valperga Caluso 35, 10125, Torino, Italy.
Ginevra MangoDepartment of Earth Sciences, University of Torino, via Valperga Caluso 35, 10125, Torino, Italy.
Kenta YamamotoPathobiology Ph.D. Program, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Roberta ParolisiDepartment of Neuroscience, University of Torino, Via Cherasco 15, 10125, Torino, Italy.
Antonio BertolottoNeuroscience Institute Cavalieri Ottolenghi (NICO), Regione Gonzole 10, 10043, Orbassano, TO, Italy.
Ruggero VigliaturoDepartment of Earth Sciences, University of Torino, via Valperga Caluso 35, 10125, Torino, Italy.
Michele MenottaDepartment of Biomolecular Sciences, University of Urbino "Carlo Bo" Campus Scientifico Enrico Mattei, Via Cà le Suore, 2, 61029, Urbino, PU, Italy.
Shan ZhaInstitute for Cancer Genes, Vagelos College for Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Filippo TempiaDepartment of Neuroscience, University of Torino, Via Cherasco 15, 10125, Torino, Italy.
Eriola HoxhaDepartment of Neuroscience, University of Torino, Via Cherasco 15, 10125, Torino, Italy. eriola.hoxha@unito.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ataxia Telangiectasia (A-T) is a neurodegenerative disorder characterized by early onset, cerebellar ataxia and progressive motor decline. The causative gene, ATM (A-T Mutated), encodes a Ser/Thr kinase, that belongs to the phosphoinositide 3-kinase-related protein kinase family and is crucial for the response to DNA double-strand breaks. While ATM is classically known for its role in the DNA damage response, increasing evidence points to its critical function in maintaining cellular homeostasis, particularly in the central nervous system (CNS). Yet the mechanisms linking ATM-kinase deficiency to cerebellar circuit dysfunction remain poorly defined. Using a CNS Nestin-Cre-restricted mouse model carrying a kinase-dead Atm allele combined with a null allele (Atm

Indexed as

Ataxia TelangiectasiaAtaxia Telangiectasia Mutated ProteinsCerebellumAnimalsDisease Models, AnimalExtracellular MatrixMaleMiceMice, KnockoutAtaxia Telangiectasia Mutated ProteinsAtm protein, mouseAtaxia Telangiectasia (A-T)Cerebellar atrophyDegenerationExcitabilityMotor deficitPurkinje cell

Identifiers

PMID42216076
PMCPMC13439767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.