Evidence map›Paper›PMID 42216073›Full record

ArticleBMC research notes2026

Callosal glia, GABAergic interneurons, and apoptotic profiles in the brains of cypermethrin-exposed male and female rats.

Oloyede Priscilla, Abdulrauf Aisha, Eduviere Faith Akpevweoghene, Oladimeji Mufutau Oladele, Olanrewaju Ridwan, Omole Precious, Afodun Adam, Danwahab Olanrewaju Ambali, Oyeniyi Joseph Oludare, Jaji-Sulaimon Rukayat and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Oloyede PriscillaDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Abdulrauf AishaDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Eduviere Faith AkpevweogheneDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Oladimeji Mufutau OladeleDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Olanrewaju RidwanDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Omole PreciousDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Afodun AdamDepartment of Anatomy, Busitema University, Mbale, Uganda.
Danwahab Olanrewaju AmbaliDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Oyeniyi Joseph OludareDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Jaji-Sulaimon RukayatDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Moyosore S AjaoDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria.
Imam AminuDepartment of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, 240003, Nigeria. imam.a@unilorin.edu.ng.ORCID http://orcid.org/0000-0003-2371-3065

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCypermethrin's effects on the corpus callosum, the brain's largest white matter tract essential for interhemispheric communication, remain unexplored, particularly regarding sex‑dependent vulnerability. We examined the effects of sub‑chronic cypermethrin exposure (6.25 and 12.5 mg/kg) on corpus callosum integrity in male and female Wistar rats, focusing on glial populations, GABAergic interneurons, and apoptosis, using biochemical (brain‑derived neurotrophic factor [BDNF] and total protein) and immunohistochemical markers (GFAP, IBA‑1, parvalbumin, cleaved caspase‑3).

resultsCypermethrin caused sex‑dependent behavioral changes: males showed increased rearing frequency while females showed decreased rearing. BDNF concentrations significantly decreased in low‑dose males (p = 0.0079) and females (p = 0.0039), with partial recovery in high‑dose females. GFAP‑positive astrocyte density decreased in exposed males but increased in low‑dose females (p = 0.024). IBA‑1‑positive microglia decreased significantly in both sexes, particularly in low‑dose groups (males: p = 0.0001; females: p = 0.0075). Parvalbumin‑positive GABAergic interneuron density decreased in low‑dose males (p = 0.029) and both female groups. Cleaved caspase‑3 expression increased in all treated groups, with high‑dose males most affected (p < 0.0001). H&E staining revealed dose‑dependent cellular density reductions, greatest in high‑dose males (p = 0.0001). Collectively, cypermethrin induced sex‑dependent white matter neurotoxicity, with males showing greater susceptibility than females.

Indexed as

ApoptosisCorpus CallosumGABAergic NeuronsInsecticidesInterneuronsNeurogliaPyrethrinsAnimalsBrain-Derived Neurotrophic FactorCaspase 3FemaleMaleRatsRats, WistarSex FactorsBrain-Derived Neurotrophic FactorCaspase 3cypermethrinInsecticidesPyrethrinsApoptosisCorpus callosumCypermethrinGABAergic interneuronsGlial cellsNeurotoxicitySex differencesWhite matter

Identifiers

PMID42216073
PMCPMC13422342

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.