Evidence map›Paper›PMID 42216048›Full record

ArticleJournal of nanobiotechnology2026

A dual-pronged strategy: multi-bioactive nanoplatform synergizes ROS antidote and iron stabilization to protect against liver ischemia-reperfusion injury.

Jie Dong, Pengqi Zhu, Caifang Gao, Qian Wang, Jin Zhang, Yahong Han, Ru Feng, Tianfeng Chen, Jinghua Sun, Ruiping Zhang

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie Dong *Department of Radiology, Shanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan, 030000, China.
Pengqi Zhu *Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Caifang Gao *Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Qian WangDepartment of Radiology, Shanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan, 030000, China.
Jin ZhangFirst Hospital of Shanxi Medical University, Taiyuan, 030001, China.
Yahong HanDepartment of Radiology, Shanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan, 030000, China.
Ru FengTongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Tianfeng ChenInstitute of Nanotechnology and Intelligence (inAI), College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China.
Jinghua SunFirst Hospital of Shanxi Medical University, Taiyuan, 030001, China. sunjh0000@163.com.
Ruiping ZhangDepartment of Radiology, Shanxi Provincial People's Hospital, Fifth Hospital of Shanxi Medical University, Taiyuan, 030000, China. zrp_7142@sxmu.edu.cn.

Funding

National Natural Science Foundation of China 82120108016the National Key R&D Program of China 2023YFC3402800
6 · The paper itself

Abstract

Liver ischemia-reperfusion injury (LIRI) is a severe and nearly unavoidable complication in hepatectomy and liver transplantation, accompanied by intense oxidative stress and ferroptosis. Traditional clinical therapies often face challenges such as poor bioavailability, short circulation time, and low stability, which restrict their efficacy in regulating complex pathological microenvironments. Here, we developed a biocompatible and multi-bioactive nanoplatform, Se@MelP, comprising a selenium nanoparticle (SeNP) core encapsulated within a melanin-like shell. Specifically, selenium (Se) was incorporated into selenoproteins in the form of selenocysteine to regulate redox reactions, while the melanin-like shell simultaneously scavenged reactive oxygen species (ROS) and chelated Fe

Indexed as

IronLiverNanoparticlesReactive Oxygen SpeciesReperfusion InjuryAnimalsFerroptosisHumansMaleMelaninsMiceMice, Inbred C57BLNF-E2-Related Factor 2Oxidative StressSeleniumIronMelaninsNF-E2-Related Factor 2Reactive Oxygen SpeciesSeleniumAMPK/Nrf2 pathwayFerroptosisIron chelationLiver ischemia-reperfusion injuryROS scavenging

Identifiers

PMID42216048
PMCPMC13435504

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.