Evidence map›Paper›PMID 42216038›Full record

ArticleJournal of biological engineering2026

Tunable PEGylation platform for efficient siRNA delivery using mesoporous silica nanoparticles.

Taeho Kim, Dongseong Seo, Jonghyun Park, Dongmin Yu, Chanju Choi, Sohyeon Yu, Jeongmin Shin, Simseok A Yuk, Daekyung Sung, Hyungjun Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Advances in carrier-free nanodrug delivery systems.Drug delivery and translational research · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taeho Kim *Department of Chemistry and Bioscience, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi, 39177, Republic of Korea.
Dongseong Seo *Center for Bio-Healthcare Materials, Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, 202 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, 28160, Republic of Korea.
Jonghyun ParkDepartment of Chemistry and Bioscience, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi, 39177, Republic of Korea.
Dongmin YuDepartment of Chemistry and Bioscience, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi, 39177, Republic of Korea.
Chanju ChoiDepartment of Chemistry and Bioscience, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi, 39177, Republic of Korea.
Sohyeon YuCenter for Bio-Healthcare Materials, Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, 202 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, 28160, Republic of Korea.
Jeongmin ShinCenter for Bio-Healthcare Materials, Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, 202 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, 28160, Republic of Korea.
Simseok A YukDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Daekyung SungCenter for Bio-Healthcare Materials, Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, 202 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, 28160, Republic of Korea. dksung@kicet.re.kr.
Hyungjun KimDepartment of Chemistry and Bioscience, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi, 39177, Republic of Korea. hyungjun@kumoh.ac.kr.

Funding

Korea Institute of Ceramic Engineering and Technology 2410002182Ministry of SMEs and Startups (MSS), Republic of Korea RS-2025-02315216
6 · The paper itself

Abstract

Poly(ethylene glycol) (PEG) coatings are widely used to improve nanoparticle stability and biocompatibility, yet conventional PEGylation methods rely on multi-step conjugation that limits reproducibility and restricts control over charge-shielding balance critical for siRNA delivery. Here, we present a composition-tunable PEGylation strategy based on poly(2-(dimethylamino)ethyl methacrylate-co-poly(ethylene glycol) methacrylate) (poly(DMAEMA-co-PEGMA), hereafter referred to as AP) copolymers for the efficient delivery of PD-L1 siRNA using mesoporous silica nanoparticles (MSNs). Copolymers with varying DMAEMA: PEGMA ratios (2:1, 1:1, 0.5:1) and PEG chain lengths (Mn 450 or 950 Da) were synthesized via one-step free-radical polymerization, enabling precise tuning of surface charge and steric stabilization. The optimized MSN/copolymer complexes exhibited enhanced siRNA loading, colloidal stability, and serum resistance while maintaining favorable cytocompatibility. Cellular studies demonstrated improved uptake and significant PD-L1 gene silencing. This work establishes a composition-tunable and scalable PEGylation platform that overcomes the limitations of conventional surface modification and provides a potential strategy for siRNA-based applications.

Indexed as

Cancer immunotherapyCationic copolymerMesoporous silica nanoparticlesNanoparticle coatingPEGylationsiRNA delivery

Identifiers

PMID42216038
PMCPMC13410597

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.