Evidence map›Paper›PMID 42215972›Full record

ArticleBMC ophthalmology2026

Accommodation-induced biometric changes in ciliary muscle, trabecular meshwork, and Schlemm's canal: comparison of eyes in high myopia.

Yilei Shao, Zixuan Li, Xueer Wu, Xiaotian Wu, Ni Wan, Hao Chen, Nan Zhe, Jingsong Wang, Yune Zhao, Yuheng Zhou and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Yilei Shao *National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Zixuan Li *National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Xueer WuNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Xiaotian WuNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Ni WanNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Hao ChenNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Nan ZheNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Jingsong WangNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Yune ZhaoNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Yuheng ZhouNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Li NieNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Yiyi WangNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Meixiao ShenNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
Fan LuNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. lufan62@mail.eye.ac.cn.
Zhangliang LiNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. 13968832833@eye.ac.cn.

Funding

Basic Scientific Research Projects in Wenzhou No.Y20220145Natural Science Foundation of Zhejiang Province No. LQ20H120002the National Key Research and Development Program of China No.2020YFC2008200the National Nature Science Foundation of China No.82471119Zhejiang Province Medical and Health Science and Technology Plan No.2023KY913
6 · The paper itself

Abstract

purposeTo evaluate accommodation-induced changes in the ciliary muscle (CM), Schlemm's canal (SC), and trabecular meshwork (TM) in eyes with and without high myopia, and to assess the associations among these structures during accommodation.

methods116 eyes from 57 healthy control (HC) and 59 high myopia (HM) were assessed across two experiments. In the first experiment, pilocarpine-induced accommodation was applied to 78 eyes, while in the second, a -5 diopter (D) accommodative stimulus was used on 38 eyes. Anterior segment images were captured via swept-source optical coherence tomography before and after each accommodation stimulus. Measurements included the maximum thickness of CM and the anterior length of CM, the length of TM, and the area of SC. Statistical analyses evaluated group differences and correlations.

resultsDrug-induced and - 5D stimulation increased the maximum thickness of CM and the area of SC's levels while decreasing the anterior length of CM's levels. In the HC group, the length of TM was larger in the accommodative state, mediating the relationship between changes in the maximum thickness of CM and the area of SC. Conversely, these changes and correlations in the length of TM were insignificant in HM eyes. The length of TM increased with axial length and elongation in the anterior length of CM across all subjects; however, accommodation-related changes diminished as axial length (AL) and the anterior length of CM increased. Causal mediation analysis demonstrated that the anterior length of CM mediated the relationship between AL and the length of TM elongation.

conclusionsIn two trials, accommodation-induced changes in the CM, TM, and SC were observed in eyes with or without HM, with reduced TM and SC response in HM. Differences in CM, TM, and SC behavior during accommodation between the HC and HM groups suggest that CM contraction may reshape the aqueous humor outflow channels.

Indexed as

Accommodation, OcularCiliary BodyMuscle, SmoothMyopia, DegenerativeSchlemm's CanalTrabecular MeshworkAdultBiometryFemaleHumansMalePilocarpineTomography, Optical CoherenceYoung AdultPilocarpineAccommodationCiliary muscleHigh myopiaOptical coherence tomographyTrabecular meshwork

Identifiers

PMID42215972
PMCPMC13435459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.