Trial reportBMC oral health2026
Effects of computer-assisted and conventional local anaesthesia on pain and anxiety in children with molar incisor hypomineralisation: a randomized controlled clinical trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07736677 (Digital Intraosseous Anesthesia in MIH-Affected Permanent Molars), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Digital Intraosseous Anesthesia in MIH-Affected Permanent Molars: A Randomized Clinical Trial
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis prospective study aimed to comparatively investigate the effects of conventional mandibular anaesthesia and digital mandibular and intraosseous anaesthesia administered using the computer-assisted local anaesthesia device (SleeperOne 5) on pain and anxiety in paediatric patients with molar incisor hypomineralisation (MIH), using physiological, projective, psychometric, and biological parameters.
methodsSixty-nine paediatric patients aged 7-12 years with a diagnosis of MIH were allocated to three groups receiving conventional mandibular anaesthesia, computer-assisted digital mandibular anaesthesia, and intraosseous anaesthesia techniques. Physiological parameters, including pulse rate and oxygen saturation, were assessed before, during, and after anaesthesia. Projective parameters, including the Visual Analogue Scale (VAS) and Wong-Baker FACES Scale (WBS), psychometric parameters, including the Facial Image Scale (FIS), Face, Legs, Activity, Cry, Consolability scale (FLACC), and Modified Child Dental Anxiety Scale (MCDAS) together with biological marker levels represented by salivary opiorphin, were evaluated before and after anaesthesia. Data analysis was performed using the licensed IBM Statistical Package for the Social Sciences Version 21 software.
resultsAcross all anaesthesia techniques, pulse rate increased during anaesthesia; however, no significant differences were observed in pulse or oxygen saturation changes among the groups (p > 0.05). Pain and anxiety levels showed significantly lower values with computer-assisted mandibular anaesthesia and intraosseous anaesthesia when compared to the conventional technique. A significant reduction in salivary opiorphin levels was observed after anaesthesia, with the greatest reduction recorded in the intraosseous anaesthesia group (p < 0.05).
conclusionsDigital anaesthesia techniques represent a comfortable and safe alternative for reducing pain and anxiety in paediatric patients with MIH. In particular, intraosseous anaesthesia demonstrated an effective role in reducing stress responses.
trial registrationTCTR identification number: TCTR20241120001; registered on 20 November 2024. The trial was registered prospectively.
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