Evidence map›Paper›PMID 42215917›Full record

SynthesisBMC psychiatry2026

Depression among women with cervical cancer: a systematic review and meta-analysis of available evidence.

Mikiyas Muche Teshale, Worku Misganaw Kebede, Wuhabie Tsega Sahilu, Kumlachew Solomon Wondimu, Habtamu Ayele, Tesfahun Ayenew, Geremew Bishaw Mekonen, Menberu Gete, Melaku Laikemariam, Getachew Tilaye Mihiret and 4 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mikiyas Muche TeshaleDepartment of Nursing, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. mikiyasmuche19@gmail.com.
Worku Misganaw KebedeDepartment of Nursing, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Wuhabie Tsega SahiluDepartment of Nursing, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Kumlachew Solomon WondimuDepartment of Midwifery, College of Medicine and Health Sciences, Debre Markos University,, Debre Markos,, Ethiopia.
Habtamu AyeleDepartment of Midwifery, College of Medicine and Health Sciences, Debre Markos University,, Debre Markos,, Ethiopia.
Tesfahun AyenewDepartment of Nursing, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Geremew Bishaw MekonenDepartment of Midwifery, College of Medicine and Health Sciences, Debre Markos University,, Debre Markos,, Ethiopia.
Menberu GeteDepartment of Nursing, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Melaku LaikemariamDepartment of Midwifery, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia.
Getachew Tilaye MihiretDepartment of Midwifery, College of Medicine and Health Sciences, Debre Markos University,, Debre Markos,, Ethiopia.
Mengistu Abebe MesseluDepartment of Nursing, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Etsudink Dessalew AbawaDepartment of Nursing, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Abraham Keffale MengistDepartments of Health Informatics, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Endalk Getasew HiruyDepartment of Nursing, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Cervical cancer remains a significant global health challenge, particularly affecting women in low- and middle-income countries. Beyond its physical implications, cervical cancer is associated with a high prevalence of depression, which adversely impacts patients' quality of life and treatment outcomes. Understanding the global prevalence and associated factors of depression among women with cervical cancer is essential for developing targeted mental health interventions and improving comprehensive cancer care. The definition and "cutting point" (threshold) of depression is a critical piece of psychiatric literature. It challenges the medical assumption that Major Depressive Disorder (MDD) is a discrete, biological category that one either "has" or "does not have."

methodsThis systematic review and meta-analysis adhered to PRISMA guidelines to assess the pooled prevalence of depression among women with cervical cancer worldwide. A comprehensive search was conducted across PubMed, Google Scholar, Science Direct, and other databases up to February 05 ,2026. Studies included were original, English-language research employing cross-sectional, case-control, cohort, or descriptive designs that reported prevalence data. Data from 20 eligible articles involving 23,825 participants were extracted and analysed using STATA version 17. A random-effects model estimated the pooled prevalence, with heterogeneity assessed via I² and subgroup analyses conducted based on study year, continent, and study design.

resultsThe pooled prevalence of depression among women with cervical cancer was estimated at 38.02% (95% CI: 29.00%, 47.05%), with significant heterogeneity (I² = 99.6%). Subgroup analysis revealed higher prevalence rates in studies conducted in Africa (52.51%) and after 2020 (49.15%), whereas studies in Europe reported lower rates (12.26%). The prevalence was higher in cross-sectional studies (48.80%) compared to other designs. Publication bias was detected, and the trim-and-fill method adjusted the pooled prevalence to approximately 24.27%. Sensitivity analysis confirmed the robustness of these findings. CONCLUSION AND RECOMMENDATIONS: Depression is highly prevalent among women with cervical cancer globally, underscoring the necessity for routine mental health screening and psychosocial support integration into cancer care. The significant heterogeneity and regional disparities highlight the importance of context-specific interventions. Healthcare providers should incorporate systematic depression screening and mental health services into cervical cancer management protocols. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

DepressionUterine Cervical NeoplasmsFemaleGlobal HealthHumansPrevalenceCervical cancerDepressionGlobal healthMental healthPrevalenceWomen

Identifiers

PMID42215917
PMCPMC13445895

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.