Evidence map›Paper›PMID 42215895›Full record

ArticleBMC cancer2026

Staining pattern and clinicopathological features of Epstein-Barr virus, Latent Membrane protein 1 expression in patients with gastric carcinoma in Lake zone, Tanzania.

Athuman Chalamila, Edrick Elias, Oscar Ottoman, Subira Matiku, Cosmas Mbulwa, Jackson Kahima, Idd Shabani, Aroan Orgenes, Alex Mremi, Peter Rambau

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Article in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Athuman ChalamilaDepartment of Pathology, St Francis University College of Health and Allied Sciences, P.O.BOX 175, Ifakara, Morogoro, Tanzania.
Edrick EliasDepartment of Pathology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania. mtalemwae@gmail.com.
Oscar OttomanDepartment of Pathology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Subira MatikuDepartment of Pathology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Cosmas MbulwaDepartment of Pathology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Jackson KahimaDepartment of Pathology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Idd ShabaniDepartment of Pathology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.
Aroan OrgenesDepartment of Pathology, Bugando Medical Centre, P.O.BOX 1370, Mwanza, Tanzania.
Alex MremiDepartment of Pathology, KCMC University, P.O. Box 2240, Moshi, Tanzania.
Peter RambauDepartment of Pathology, Bugando Medical Centre, P.O.BOX 1370, Mwanza, Tanzania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfectious agents such as the Epstein-Barr virus are responsible for 10% of gastric carcinomas worldwide. The lake zone in Tanzania lies in an Epstein-Barr virus-endemic (EBV) belt, and the contribution of EBV-related gastric carcinoma has not yet been established. Therefore, this study aimed to investigate the prevalence, staining pattern and clinicopathological features of EBV-related gastric carcinoma at Bugando Medical Center.

methodsThis was a cross-sectional study conducted at Bugando Medical Center. Latent membrane protein-1, stained on formalin-fixed paraffin-embedded (FFPE) tissue blocks, to determine the prevalence and staining pattern of EBV-associated Gastric carcinoma. Data was entered and cleaned in Excel and then analyzed using STATA version 15. The Chi-square tests were used to assess associations at a significant level of p < 0.05.

resultsA total of 119 cases were evaluated, with 70 (58.8%) males and 49 (41.2%) females. The prevalence of LMP-1 overexpression was 48(40.3%). LMP-1 positive cases were significantly associated with age 45-60 years, poor differentiation and diffuse histological type. The expression pattern was predominantly nuclear in 37(77.1%), while 11(22.9%) were nuclear and cytoplasmic.

conclusionsGastric carcinoma in our setting showed a high level of LMP-1 overexpression. These findings suggest that all patients aged 45-60 years, with poorly differentiated carcinoma and diffuse histological type, should be screened for LMP-1 overexpression as a predictive marker for targeted therapy and favorable prognostication.

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanStomach NeoplasmsViral Matrix ProteinsAdultAgedCross-Sectional StudiesFemaleHumansImmunohistochemistryMaleMiddle AgedTanzaniaEBV-associated membrane antigen, Epstein-Barr virusViral Matrix ProteinsAdenocarcinomaEBV Latent membrane protein 1GastricImmunohistochemistry

Identifiers

PMID42215895
PMCPMC13435426

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