Evidence map›Paper›PMID 42215887›Full record

ArticleBMC cardiovascular disorders2026

Nomogram prediction of acute kidney injury following modified Morrow myectomy in hypertrophic obstructive cardiomyopathy: insights from 12 years of outcomes.

Xiaodong Zeng, Yuemei Liang, Yijin Wu, Hongxiang Wu, Ruobing Wang, Pingchuan Huang, Xuan Xu, Ying Zeng, Minjie Huang, Xinze Song and 3 more

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Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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13 authors.

Xiaodong Zeng *Department of Cardiac Surgery Intensive Care Unit, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Yuemei Liang *Guangzhou Health Science College, Guangzhou, China.
Yijin Wu *Department of Cardiac Surgery Intensive Care Unit, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Hongxiang WuGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Ruobing WangGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Pingchuan HuangGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Xuan XuGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Ying ZengGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Minjie HuangGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Xinze SongGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Jimei ChenDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. chenjimei@gdph.org.cn.
Liming LeiDepartment of Cardiac Surgery Intensive Care Unit, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. leiliming@gdph.org.cn.
Huiming GuoDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. guohuiming@gdph.org.cn.

Funding

2023 Stability Support for Innovative Capacity Building of Guangdong Provincial Scientific Research Institutions No. KD022023019Clinical High-Tech and Major Technologies of Guangzhou 2023P-ZD09Guangzhou Science and Technology Planning Project 2023B03J0596National Key Research and Development Program of China No. 2022YFC2407406National Key Research and Development Project of China No. 2023ZD0504405-1National Natural Science Funds of China No. 82270308Noncommunicable Chronic Diseases - National Science and Technology Major Project Grant No. 2025ZD0547500, Subproject No. 2025ZD0547501Noncommunicable Chronic Diseases-National Science and Technology Major Project 2025ZD0547300Science and Technology Fundation of Guangzhou Health No. 2023A031004
6 · The paper itself

Abstract

objectiveThis study explored the incidence and risk factors of acute kidney injury (AKI) in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing modified Morrow septal myectomy and developed a risk prediction model to optimize perioperative management.

methodsA retrospective cohort of HOCM patients who underwent modified Morrow procedure between 2012 and 2024 was analyzed. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria, and patients were grouped into AKI and non-AKI cohorts. Univariate analysis followed by binary logistic regression identified independent predictors of AKI, which informed the development of a nomogram-based prediction model. Model performance was assessed using the concordance index (C-index), calibration curves, and decision curve analysis.

resultsAmong 270 patients, 54 (20%) developed AKI, including 24, 12, and 18 patients classified as stage 1, stage 2, and stage 3 respectively, with 15 requiring hemodialysis. Independent predictors included preoperative creatinine (OR = 1.069, P < 0.001), postoperative 48-h alanine aminotransferase (ALT) (OR = 1.001, P = 0.021), total bilirubin (TBIL) (OR = 1.036, P = 0.015), pulmonary infection (OR = 9.432, P < 0.001), and red blood cell transfusion (OR = 1.246, P = 0.002). The logistic model achieved 81.13% sensitivity, 87.91% specificity, and an AUC of 0.904 (95% CI: 0.862 ~ 0.936). The nomogram showed excellent accuracy, with a C-index of 0.890.

conclusionAKI is a frequent and severe complication after modified Morrow myectomy in HOCM. Identifying high-risk patients and addressing modifiable factors may improve perioperative management and outcomes.

Indexed as

Acute Kidney InjuryCardiomyopathy, HypertrophicDecision Support TechniquesNomogramsSeptal MyectomyAgedFemaleHumansIncidenceMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsAcute kidney injuryHypertrophic obstructive cardiomyopathyModified morrow septal myectomyNomogramRisk factorsRisk prediction model

Identifiers

PMID42215887
PMCPMC13439895

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