Evidence map›Paper›PMID 42215879›Full record

ArticleBMC plant biology2026

miR156-StSPL9 regulating the biosynthesis of flavonoids and secondary metabolites in potato tubers.

Nan Li, Hushuai Nie, Xiaojuan Wu, Peijie Wang, Yu Ma, Enze Yang, Juan Wu, Zhicheng Zhang, Rui Xie, Dan Wang and 1 more

Abstract read
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In one paragraph

Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Nan LiAgricultural College, Inner Mongolia Agricultural University, Hohhot, 010019, China.
Hushuai NieAgricultural College, Inner Mongolia Agricultural University, Hohhot, 010019, China.
Xiaojuan WuAgricultural College, Inner Mongolia Agricultural University, Hohhot, 010019, China.
Peijie WangAgricultural College, Inner Mongolia Agricultural University, Hohhot, 010019, China.
Yu MaAgricultural College, Inner Mongolia Agricultural University, Hohhot, 010019, China.
Enze YangAgricultural College, Inner Mongolia Agricultural University, Hohhot, 010019, China.
Juan WuInner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot, 010031, China.
Zhicheng ZhangAgricultural College, Inner Mongolia Agricultural University, Hohhot, 010019, China.
Rui XieInner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot, 010031, China.
Dan WangCollege of Life Sciences and Technology, Jining Normal University, Ulanqab, 012000, China.
Yanhong MaAgricultural College, Inner Mongolia Agricultural University, Hohhot, 010019, China. mayanhong80@imau.edu.cn.

Funding

Breeding Joint Research Project of Inner Mongolia Autonomous Region of China YZ2023006Industrial Technology Innovation Program of IMAST No. 2024RCYJ04004Natural Science Foundation of Inner Mongolia Autonomous Region of China 2022JQ06Natural Science Foundation of Inner Mongolia Autonomous Region of China 2024QN03070Postgraduate Scientific Research Innovation Project of Inner Mongolia Autonomous Region S20231102ZSpecial Funds for Basic Scientific Research Operating Expenses of Inner Mongolia Agricultural University BR22-11-16
6 · The paper itself

Abstract

The colored potatoes exhibit enhanced nutritional value due to their rich flavonoid content. Flavonoids are a class of compounds that confer a wide range of colors to plants, significantly influencing the color and quality of various plant species. Elucidating the mechanisms underlying flavonoid biosynthesis will provide important insights applicable to enhancing flavonoid accumulation in potato varieties. Through transient expression assays, we confirmed that StSPL9 is a target of miR156a. Functional studies revealed that miR156a overexpression reduces flavonoid content, a phenotype reversed by STTM-miR156a. Expanding on this, integrated multi-omics analyses demonstrated that the miR156a-StSPL9 module plays a systematic regulatory role in the biosynthesis pathways of flavonoids and anthocyanins in potato tubers. These results suggest that key downstream flavonoid pathway genes (e.g., CHS2, F3H, HST, CHS1A, BEATH, CHIL2, F3'5'H, FGGT1, and U79B6) may be regulated by miR156a-StSPL9 module, potentially contributing to the increased accumulation of hesperetin, kaempferol, and quercetin in potato tubers. By elucidating miR156a-StSPL9 regulatory module, this work provides novel insights into the metabolic networks of Solanum species and thereby establishes a foundation for the enhancement of nutritional quality in potatoes.

Indexed as

FlavonoidsMicroRNAsPlant ProteinsPlant TubersRNA, PlantSolanum tuberosumAnthocyaninsGene Expression Regulation, PlantSecondary MetabolismAnthocyaninsFlavonoidsMicroRNAsPlant ProteinsRNA, PlantAnthocyaninsFlavonoidsMiR156aSolanum tuberosumStSPL9

Identifiers

PMID42215879
PMCPMC13295644

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.