ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Temporal patterns of neurological deterioration in COVID-19 survivors: a longitudinal cohort analysis of post-acute neurological sequelae.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-acute neurological sequelae of COVID-19 represent a significant clinical challenge. The temporal evolution and predictive factors remain incompletely characterized.
methodsWe conducted a retrospective longitudinal cohort study of 386 COVID-19 survivors with assessments at baseline and 3, 6, 12, and 24 months. Primary outcomes included cognitive function (Montreal Cognitive Assessment [MoCA]), peripheral nerve function (nerve conduction studies [NCS]), and autonomic function (Composite Autonomic Symptom Score-31 [COMPASS-31]).
resultsAmong 386 participants (mean age 51.92±14.86 years; 53.9% female), cognitive impairment prevalence decreased from 67.6% at baseline to 43.4% at 24 months (P<0.001). Mean MoCA scores improved from 24.61±2.12 to 25.84±2.31. Autonomic dysfunction demonstrated a biphasic pattern with worsening at 6 months (COMPASS-31: 38.49±22.13 vs. 32.81±19.11 at 3 months). Peripheral neuropathy remained stable (42.5% to 45.0%). Independent predictors of persistent cognitive impairment included ICU admission (adjusted odds ratio [aOR] 2.84; 95% CI 1.52-5.31), age ≥65 years (aOR 1.95; 95% CI 1.18-3.22), and depression history (aOR 1.92; 95% CI 1.08-3.41).
conclusionsNeurological sequelae following COVID-19 demonstrate domain-specific recovery trajectories. Cognitive function improves gradually, autonomic dysfunction exhibits a biphasic pattern, and peripheral neuropathy persists. These findings support targeted, domain-specific rehabilitation strategies.
Indexed as
Identifiers
42215824What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.