ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Resting-state EEG markers of cognitive dysfunction in epilepsy: evidence from gamma power, alpha activity, and functional connectivity.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCognitive dysfunction is a common comorbidity in epilepsy, linked to disrupted neural oscillations and network synchronization. Resting-state electroencephalography (EEG) provides a non-invasive approach to identify electrophysiological biomarkers of cognitive dysfunction. This study examined relationships between resting-state EEG spectral power, functional connectivity, and cognitive performance among people with epilepsy.
methodsSixty-five persons with epilepsy (mean age 38.72 ± 1.63 years) underwent eyes-closed resting-state EEG and Montreal Cognitive Assessment (MoCA). Participants were classified into preserved cognition (nPCCD; MoCA ≥ 26, n = 35) and comorbid cognitive dysfunction (PCCD; MoCA < 26, n = 30) groups. Power spectral density (PSD) and band-powers were extracted from clean EEG, and functional connectivity was assessed via magnitude-squared coherence. Pearson correlations assessed associations between MoCA and band-powers, and group comparisons evaluated inter-group differences.
resultsGlobal gamma power negatively correlated with MoCA scores all (r= -0.30, p = 0.01, n = 65) and PCCD group (r= -0.57, p = 0.0003), indicating higher gamma activity with poorer cognition. The nPCCD group exhibited higher global alpha power than the PCCD group [17.48 ± 2.63 vs. 10.83 ± 1.76 µV²/Hz, p = 0.0091], with topographic significance over bilateral temporal and parietal regions (15 channels, p < 0.05). Functional connectivity differed between groups across frequency bands, most prominently in alpha. (p < 0.05).
conclusionsResting-state EEG reveals elevated gamma power significantly correlates with poorer cognitive performance across all participants as well as PCCD, and also reduced alpha power, and altered functional connectivity as neurophysiological markers of cognitive dysfunction in epilepsy. Combining spectral and network-level measures may improve characterization, early identification, and targeted management of cognitive comorbidity in epilepsy.
Indexed as
Identifiers
42215811What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.