Evidence map›Paper›PMID 42215785›Full record

SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Prevalence of Central Compartment Atopic Disease (CCAD): a systematic review and meta-analysis.

Robbi Miguel G Falcon, Ma Angela Diarota, Ross Ivan T Gammad, Rona Angela D Grindulo, Gabrielle Anne P Mata, Christine B Porras, Mark Joseph R Remucal, Cyril Francis T Wakit, Kimberly Mae O Nelson, Teresa Luisa G Cruz

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Robbi Miguel G FalconCollege of Medicine, University of the Philippines Manila, Manila, Philippines. rgfalcon@up.edu.ph.ORCID https://orcid.org/0009-0007-9655-2270
Ma Angela DiarotaCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Ross Ivan T GammadCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Rona Angela D GrinduloCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Gabrielle Anne P MataCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Christine B PorrasCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Mark Joseph R RemucalCollege of Medicine, University of the Philippines Manila, Manila, Philippines.ORCID http://orcid.org/0009-0008-1898-0090
Cyril Francis T WakitCollege of Medicine, University of the Philippines Manila, Manila, Philippines.
Kimberly Mae O NelsonCollege of Medicine, University of the Philippines Manila, Manila, Philippines.ORCID http://orcid.org/0000-0002-1151-3368
Teresa Luisa G CruzCollege of Medicine, University of the Philippines Manila, Manila, Philippines.ORCID http://orcid.org/0000-0001-9164-1492

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCentral compartment atopic disease (CCAD) is a subtype of chronic rhinosinusitis characterized by polypoid edema and mucosal changes localized to the central sinonasal compartment, particularly the middle turbinate, superior turbinate, and posterosuperior nasal septum, in association with inhalant allergy. Despite increasing recognition, its epidemiologic burden remains poorly defined.

methodsAll studies reporting the proportion of CCAD among CRS were extracted from OVID Medline, Scopus, and EBSCO CINAHL. A review of title and abstracts was done independently by seven reviewers. The quality of the studies was assessed using the Newcastle-Ottawa scale. Meta-analysis was performed using R v.4.1.1, using the 'meta', 'tidyverse', and 'metafor' packages (version 4.19-0).

resultsSeven studies from the United States and Asia were included in the study. The pooled proportion of CCAD was 23.0% (95% CI 15.0%-33.0%). Subgroup analyses suggested variability by region being higher in Asia and sex, showing higher prevalence in males; however, these analyses were exploratory in nature and intended to identify potential sources of heterogeneity rather than establish definitive subgroup differences.

conclusionCCAD represents a substantial proportion of chronic rhinosinusitis with nasal polyps (CRSwNP) cases globally, though estimates are limited by marked heterogeneity and inconsistent diagnostic criteria. Standardized case definitions and wider geographic surveillance are essential to better characterize the global burden and phenotypic diversity of CCAD.

Indexed as

Nasal PolypsRhinosinusitisAsiaChronic DiseaseHumansPrevalenceUnited StatesCentral compartment atopic diseaseMeta-analysisPrevalenceSystematic review

Identifiers

PMID42215785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.