Evidence map›Paper›PMID 42215715›Full record

ArticleCommunications biology2026

GOT2-mediated suppression of CoQ

Han Zhang, Xinsheng Gu, Yidan Sun, Pengcheng Chen, Qiangsheng Hu, Hao Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Han Zhang *Department of Cardiology, Shanghai Xuhui Central Hospital & Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China.
Xinsheng Gu *Department of Cardiology, Shanghai Eighth People's Hospital, Shanghai, China.
Yidan Sun *Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Pengcheng ChenDepartment of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, China. cpc_pf@163.com.ORCID 0000-0003-1549-1474
Qiangsheng HuDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. 2011085@tongji.edu.cn.
Hao LiDepartment of Cardiology, Shanghai Xuhui Central Hospital & Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China. lihaoroni@163.com.ORCID 0009-0007-6343-6871

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82403099
6 · The paper itself

Abstract

The roles of glutamic-oxaloacetic transaminase 2 (GOT2) in malate-aspartate shuttle (MAS), fatty acid binding/trafficking, and peroxisome proliferator-activated receptor (PPAR) delta axis have been documented. However, its function in ferroptosis remains unexplored. Here, we report that GOT2 promotes ferroptosis by disturbing mitochondrial redox homeostasis through inhibiting the synthesis of radical scavenger coenzyme Q10 (CoQ

Indexed as

Adenocarcinoma of LungAspartate Aminotransferase, MitochondrialAtherosclerosisFerroptosisLung NeoplasmsUbiquinoneAMP-Activated Protein KinasesAnimalsCell Line, TumorHumansMitochondriaPPAR alphaAMP-Activated Protein KinasesAspartate Aminotransferase, Mitochondrialcoenzyme Q10PPAR alphaUbiquinone

Identifiers

PMID42215715
PMCPMC13503677

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.