Evidence map›Paper›PMID 42215694›Full record

ArticleCommunications biology2026

Pathogenic Ca

Takashi Murayama, Takuro Numaga-Tomita, Hirotsugu Miyoshi, Tsuyoshi Ikeda, Keiko Mukaida, Takuya Kobayashi, Nagomi Kurebayashi, Tsutomu Nakada, Taichiro Tomida, Satomi Adachi-Akahane and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Takashi Murayama *Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan. takashim@juntendo.ac.jp.ORCID 0000-0002-3845-2980
Takuro Numaga-Tomita *Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan. ta96tomita@shinshu-u.ac.jp.ORCID 0000-0003-0240-4474
Hirotsugu MiyoshiDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan.
Tsuyoshi IkedaDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan.
Keiko MukaidaDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan.
Takuya KobayashiDepartment of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.ORCID 0000-0003-3992-1889
Nagomi KurebayashiDepartment of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.ORCID 0000-0002-5005-9698
Tsutomu NakadaDepartment of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Taichiro TomidaDepartment of Physiology, Faculty of Medicine, Toho University, Tokyo, Japan.ORCID 0000-0002-1950-4896
Satomi Adachi-AkahaneDepartment of Physiology, Faculty of Medicine, Toho University, Tokyo, Japan.
Yasuo M TsutsumiDepartment of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan.
Mitsuhiko YamadaDepartment of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Takashi SakuraiDepartment of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.ORCID 0000-0001-9515-6574

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant hyperthermia (MH) is a potentially fatal genetic disorder triggered by certain anesthetics, leading to excessive calcium release in skeletal muscle. While most MH-associated mutations affect the type 1 ryanodine receptor, a Ca

Indexed as

CalciumCalcium Channels, L-TypeMalignant HyperthermiaCaffeineHEK293 CellsHumansMembrane PotentialsMutationCaffeineCalciumCalcium Channels, L-Type

Identifiers

PMID42215694
PMCPMC13221468

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.