Evidence map›Paper›PMID 42215665›Full record

ArticlePediatric research2026

Association of complete blood count parameters with adverse outcomes in acute pediatric pneumonia.

Lin Han, Ying Yang, Yanhao Huang, Na Zang, Enmei Liu

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Lin HanDepartment of Respiratory Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Ying YangDepartment of Respiratory Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Yanhao HuangDepartment of Respiratory Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Na ZangDepartment of Respiratory Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China. zangna1214@126.com.
Enmei LiuDepartment of Respiratory Medicine Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China. emliu186@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPediatric pneumonia remains a leading cause of under-5 mortality worldwide. Emerging evidence suggests that complete blood count (CBC) parameters may serve as predictive indicators for acute clinical deterioration. This study aimed to identify a cost-effective, rapid, and reliable biomarker for predicting adverse outcomes in pediatric pneumonia within outpatient and primary care settings.

methodsThis retrospective case-control study analyzed 15,359 pediatric pneumonia admissions at a tertiary hospital between 2015 and 2022. Using restricted cubic splines (RCS), multivariable logistic regression, and receiver operating characteristic (ROC) curve, this study evaluated the correlation between seven CBC parameters - hemoglobin (Hb), platelet (PLT), neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW), absolute neutrophil count (ANC), lymphocyte absolute value (LYM), and white blood cell count (WBC) - and adverse outcomes in pediatric pneumonia.

resultsSevere cases exhibited reduced Hb, PLT, and LYM (all P < 0.001) and elevated RDW, ANC, and NLR (all P < 0.001). Multivariable logistic analysis identified Hb and PLT as independent negative predictors, while NLR and RDW as independent positive predictors for adverse outcomes (P < 0.001). NLR demonstrated superior predictive performance, followed by Hb. Combining NLR and Hb significantly enhanced predictive capacity.

conclusionsWe found that CBC parameters, particularly NLR and Hb, were robust, accessible predictors of adverse outcomes in pediatric pneumonia. Their integration into risk stratification protocols could optimize clinical decision-making, especially in resource-limited settings. IMPACT: This study identified Hb, PLT, NLR, and RDW as independent predictors of adverse outcomes in pediatric pneumonia. NLR demonstrated the strongest predictive performance, and its combination with Hb significantly enhanced risk stratification These low-cost, readily available indices offered a practical tool for rapid triage in primary care and resource-constrained settings.

Identifiers

PMID42215665

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.