ArticleJournal of materials science. Materials in medicine2026
Antiseptic chitosan acetate-chlorhexidine spray for wound cleaning.
Article in Journal of materials science. Materials in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- A bioinspired long-acting chlorhexidine-eluting super-hydrophilic coating on vascular catheters prevents thrombosis and biofouling.Bioactive materials · 2027Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of microbial biofilms in acute and chronic wound infections creates a significant dermal complication as these biofilms interfere with wound healing and complicate the regenerative process. Effective cleaning of wound bed remains essential because it eliminates necrotic materials, biofilms, and contaminants leading to faster treatment and decreased secondary infections. A novel antiseptic spray formulation using chitosan acetate (CA) and chlorhexidine (CHX) was developed aiming infection control. In the present study, an antiseptic CA-CHX spray, with poly (vinyl alcohol) (PVA) as the film-forming agent was formulated. FTIR studies confirmed the incorporation of CHX in the CA-CHX spray. FESEM images showed spherical shape of the particles with an average size of 1μm. The CA-CHX spray exhibited excellent spraying ability, remarkable film-forming property and stability across different temperature ranges. In vitro antibacterial and anti-biofilm activity was studied against Escherichia coli, Staphylococcus aureus, and MRSA. In vivo fly infection model using wild-type Drosophila melanogaster further proved antibacterial property of the CA-CHX spray against these bacteria. To understand the cytotoxicity effect of CA and CA-CHX spray, cell viability study was conducted against the L929 cells. These research findings demonstrated that the developed antiseptic CA-CHX spray could be effectively used for wound cleaning.
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