Evidence map›Paper›PMID 42215611›Full record

SynthesisScientific reports2026

Association between emotion recognition and cognitive functioning in multiple sclerosis: a multilevel correlational meta-analysis.

Béatrice Degraeve, Audrey Henry, Bruno Lenne

Abstract readMeta-Analysis
In one paragraph

Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Béatrice DegraeveNeurethic Lab / FLSH - ETHICS EA7446, Université Catholique de Lille, F-59000, Lille, France. beatrice.degraeve@univ-catholille.fr.ORCID http://orcid.org/0000-0001-5805-0981
Audrey HenryUniversité de Reims Champagne-Ardenne, Laboratoire C2S (ER 6291), Reims, France.ORCID http://orcid.org/0000-0002-5377-1779
Bruno LenneNeurethic Lab / FLSH - ETHICS EA7446, Université Catholique de Lille, F-59000, Lille, France.ORCID http://orcid.org/0000-0002-2150-705X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease marked by both cognitive and socio-cognitive impairments, including difficulties in recognizing emotions. While deficits in processing speed, executive functions, and episodic memory are well known, growing evidence also points to impairments in emotion-recognition, particularly for negative emotions such as fear, sadness, or disgust. However, the extent to which these socio-cognitive difficulties are linked to broader cognitive dysfunction remains unclear, as individual studies report inconsistent findings. This meta-analysis synthesized data from 23 independent studies (k = 774 correlations) using multilevel random-effects models to quantify the association between emotion-recognition and cognitive functioning in MS. Overall, results revealed small to moderate associations between emotion-recognition and cognitive performance, with stronger effects for negative emotions and for total emotion scores. Processing speed and executive functions exhibited broad associations, while episodic memory effects were more emotion-specific. At the subdomain level, working memory and verbal fluency emerged as key correlates. However, substantial heterogeneity across studies should be noted. Additional meta-regressions indicated that higher disability and anxiety were associated with stronger emotion-cognition links, whereas longer disease duration and depression predicted weaker associations. These findings indicate that emotion-recognition deficits in MS seem partially connected to neurocognitive dysfunctions.Trial registration: The preregistered review protocol can be accessed at https://doi.org/10.17605/OSF.IO/3VNA4 .

Indexed as

CognitionEmotionsMultiple SclerosisRecognition, PsychologyExecutive FunctionHumansProcessing SpeedCognitive impairmentEmotion recognitionMeta-analysisMultiple sclerosisSocial cognition

Identifiers

PMID42215611
PMCPMC13493921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.