Evidence map›Paper›PMID 42215510›Full record

ArticleScientific reports2026

Efficacy of Sr

Locherla Daloji, Raghavendra Gujjala, Shakuntala Ojha, G Dheeraj Kumar, Prakash Saudagar, Manuela Reben, P Syam Prasad, Aswani Kumar Bandaru

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Locherla DalojiDepartment of Mechanical Engineering, National Institute of Technology, Warangal, India.
Raghavendra GujjalaDepartment of Mechanical Engineering, National Institute of Technology, Warangal, India. raghavendra.gujjala@nitw.ac.in.
Shakuntala OjhaDepartment of Mechanical Engineering, PACE Institute of Technology and Sciences, Ongole, India.
G Dheeraj KumarDepartment of Aerospace Engineering, Jain University, Bengaluru, Karnataka, 562112, India. garadheeraj.kumar@jainuniversity.ac.in.
Prakash SaudagarDepartment of Biotechnology, National Institute of Technology Warangal, Warangal, Telangana, 506004, India.
Manuela RebenFaculty of Materials Science and Ceramics, AGH-University of Science and Technology, Al. Mickiewicza 30, 30-059, Cracow, Poland.
P Syam PrasadDepartment of Physics, National Institute of Technology Warangal, Warangal, Telangana, 506004, India.
Aswani Kumar BandaruSchool of Engineering, Bernal Institute, University of Limerick, Limerick, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inclusion of the metal based therapeutic ions into bioactive glasses received potential towards tissue regeneration applications due to their excellent biocompatible, mechanical and wear properties. In the current work, one such configuration is chosen, strontium (Sr) and Copper (Cu) ions based bioactive borosilicate glass system i.e., [Formula: see text] with varying composition of Sr and Cu for 0, 1 and 2 wt.%. The glasses were prepared through melt quench process and the as prepared specimens are characterized for their microstructural, mechanical, tribological, biocompatible and biological investigations. The results were found to appealing with microstructure and crystallographic peaks displaying the presence of extracted natural Silica (Si) and Calcium (Ca) powders. Further the same specimens are characterized for their mechanical strength and it was found to be 55.21MPa compressive strength and lowest specific wear rate overall for CuSr-1 wt.% composition. Being CuSr-1% displaying better mechanical properties, the same samples i.e., Cu, Sr for 1wt.%, were investigated for their biocompatible studies through Simulated Body Fluid immersion protocol. The SBF studies indicate the formation of hydroxyapatite that can be inferred from crystallographic peaks and Fourier Transform Infrared Spectroscopy. The samples were also exposed to antibacterial studies against Escherichia coli (E. coli) and Staphylococcus aureus (S.aureus) and are found to exhibit excellent antibacterial activity. The observed selective antibacterial activity highlights the potential of these bioactive glasses as advanced materials for load-bearing orthopaedic implants and bone tissue engineering scaffolds, where the simultaneous requirements of mechanical robustness and antimicrobial efficacy are critical for clinical success.

Indexed as

Anti-Bacterial AgentsBiocompatible MaterialsCopperGlassProstheses and ImplantsSilicatesStrontiumEscherichia coliHumansMaterials TestingStaphylococcus aureusAnti-Bacterial AgentsBiocompatible MaterialsCopperSilicatesStrontiumAntibacterial activityBorosilicate bioactive glassCytocompatibilityMechanical performanceMG-63 osteoblast-like cells

Identifiers

PMID42215510
PMCPMC13454597

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