Evidence map›Paper›PMID 42215492›Full record

ArticleNature communications2026

Controlled sweat generation via ultrasound stimulation integrated in a wearable device.

Litong Chen, Benxing Su, Geng Zhong, Jing Wang, Yongxiang Ji, Zhongzeng Zhou, Xuecheng He, Tailin Xu

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Litong ChenCollege of Chemistry and Environmental Engineering, Synthetic Biology Research Center of Shenzhen University, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, 518060, PR China.ORCID http://orcid.org/0009-0001-1715-8520
Benxing SuCollege of Chemistry and Environmental Engineering, Synthetic Biology Research Center of Shenzhen University, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, 518060, PR China.
Geng ZhongCollege of Chemistry and Environmental Engineering, Synthetic Biology Research Center of Shenzhen University, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, 518060, PR China.
Jing WangCollege of Chemistry and Environmental Engineering, Synthetic Biology Research Center of Shenzhen University, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, 518060, PR China.ORCID http://orcid.org/0000-0001-7533-509X
Yongxiang JiCollege of Chemistry and Environmental Engineering, Synthetic Biology Research Center of Shenzhen University, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, 518060, PR China.
Zhongzeng ZhouCollege of Chemistry and Environmental Engineering, Synthetic Biology Research Center of Shenzhen University, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, 518060, PR China.
Xuecheng HeAiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California San Diego, La Jolla, CA, USA. xuecheng.he@ucf.edu.ORCID http://orcid.org/0000-0003-3702-8915
Tailin XuCollege of Chemistry and Environmental Engineering, Synthetic Biology Research Center of Shenzhen University, Institute for Advanced Study, Shenzhen University, Shenzhen, Guangdong, 518060, PR China. xutailin@szu.edu.cn.ORCID http://orcid.org/0000-0003-4037-2856

Funding

Shenzhen Science and Technology Innovation Commission JCYJ20240813142503006
6 · The paper itself

Abstract

Wearable sweat biosensors enable noninvasive molecular monitoring, but reliable and comfortable on-demand sweat induction remains challenging. We developed a soft, skin-conformal wearable device that integrates ultrasound-assisted sweat generation with electrochemical sensing. Low-frequency ultrasound enhanced transdermal delivery of carbachol from a hydrogel reservoir, inducing localized sweat secretion under resting conditions without electrical current or skin penetration. Under the matched 15-min experimental window used here, ultrasound-induced sweating showed lower observed skin irritation and more favorable user-rated comfort than the tested iontophoresis setting. Integrated sensors measured uric acid, pH and K+ in ultrasound-induced sweat, and sweat uric acid showed a positive correlation with serum levels in a preliminary human study. These results support wearable ultrasound as a low-irritation strategy for controlled sweat generation and downstream biomarker tracking under resting conditions.

Indexed as

Biosensing TechniquesSweatSweatingUltrasonic WavesWearable Electronic DevicesHumansHydrogen-Ion ConcentrationIontophoresisPotassiumSkinUric AcidPotassiumUric Acid

Identifiers

PMID42215492
PMCPMC13388913

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.