Evidence map›Paper›PMID 42215488›Full record

ArticleNature communications2026

Structural characterization of kappa-opioid receptor dimer in complex with two G proteins.

Yuxi Zhao, Chanjuan Xu, Yue Wang, Hong Shan, Jing Wang, Yuxuan Liu, Xin Luo, Junrui Li, Mingyang Li, Yini Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuxi Zhao *State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Chanjuan Xu *Cellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.ORCID http://orcid.org/0000-0002-5640-1896
Yue Wang *State Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.ORCID http://orcid.org/0000-0002-3716-2922
Hong ShanState Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Jing WangDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0009-0006-3929-9267
Yuxuan LiuCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.ORCID http://orcid.org/0009-0007-0799-3227
Xin LuoCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China.
Junrui LiState Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Mingyang LiDepartment of Pharmaceutical and Artificial-Intelligence Sciences, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Yini LiuDepartment of Pharmaceutical and Artificial-Intelligence Sciences, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Kai WuState Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Bryan L RothDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0002-0561-6520
Xi-Ping HuangDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.ORCID http://orcid.org/0000-0002-2585-653X
H Eric XuState Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. eric.xu@simm.ac.cn.ORCID http://orcid.org/0000-0002-6829-8144
Jianfeng LiuCellular Signaling laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China. jfliu@mail.hust.edu.cn.ORCID http://orcid.org/0000-0002-0284-8377
Youwen ZhuangState Key Laboratory of Drug Research. Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. youwen_zhuang@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-1380-8047

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32401002
6 · The paper itself

Abstract

The κ-opioid receptor (κOR) represents a promising non-addictive analgesic target due to its critical role in pain and reward pathways. Despite evidence of κOR dimerization, its molecular basis and pharmacological significance remain elusive. Here, we demonstrate stable κOR dimer formation in living cells and present cryo-electron microscopy structures of salvinorin A-bound κOR dimer complexed with two G

Indexed as

GTP-Binding ProteinsReceptors, Opioid, kappaAnimalsCryoelectron MicroscopyDiterpenes, ClerodaneHEK293 CellsHumansModels, MolecularProtein BindingProtein MultimerizationDiterpenes, ClerodaneGTP-Binding ProteinsReceptors, Opioid, kappasalvinorin A

Identifiers

PMID42215488
PMCPMC13392027

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.