Evidence map›Paper›PMID 42215481›Full record

Reviewnpj aging2026

Psychosis as a multisystem disorder of aberrant aging.

Rachel Upthegrove, Amalie C M Couch, Antonio de Marvao, Benjamin I Perry, Fabiana Corsi-Zuelli, Jack Rogers, Lahiru Handunnetthi, Nicholas M Barnes, Nikolaos Koutsouleris, Paris A Lalousis and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rachel UpthegroveDepartment of Psychiatry, University of Oxford, Oxford, UK. rachel.upthegrove@psych.ox.ac.uk.
Amalie C M CouchDepartment of Psychiatry, University of Oxford, Oxford, UK.
Antonio de MarvaoDepartment of Women and Children's Health, King's College London, London, UK.
Benjamin I PerryInstitute for Mental Health, University of Birmingham, Birmingham, UK.
Fabiana Corsi-ZuelliDepartment of Psychiatry, University of Oxford, Oxford, UK.
Jack RogersInstitute for Mental Health, University of Birmingham, Birmingham, UK.
Lahiru HandunnetthiDepartment of Psychiatry, University of Oxford, Oxford, UK.
Nicholas M BarnesInstitute of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Nikolaos KoutsoulerisMax Planck Institute of Psychiatry, Munich, Germany.
Paris A LalousisDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, London, UK.
Toby PillingerDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, London, UK.
Zachary FreybergDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

NIHR NIHR203316
6 · The paper itself

Abstract

Psychotic disorders, including schizophrenia and affective psychosis, affect ~3% of the population and typically emerge in early adulthood. Cardiometabolic disease accounts for much of the 20-year life-expectancy gap in psychosis. Evidence indicates potentially causal processes, often seen in aging, act within and beyond the brain, and before the onset of treatment; these include inflammation, metabolic and mitochondrial dysfunction. Here we synthesize evidence and propose a framework that proposes psychosis as a multisystem disorder of accelerated aging, and outline implications for aging-targeted interventions.

Identifiers

PMID42215481
PMCPMC13507340

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.