Evidence map›Paper›PMID 42215445›Full record

ArticleCell death & disease2026

Ripk2 promotes CD8

Zengbin Wang, Huahui Yu, Le Yu, Mengxin Liu, Xuemei Huang, Linqing Wu, Wenhao Teng, Shiguang Chen, Zhuting Fang

Abstract read
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zengbin Wang *Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China. wangzengbin@fjmu.edu.cn.ORCID http://orcid.org/0000-0003-0793-1361
Huahui Yu *Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China.
Le Yu *Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China.
Mengxin LiuDepartment of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China.
Xuemei HuangDepartment of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China.
Linqing WuDepartment of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China.
Wenhao TengDepartment of Hepatopancreatobiliary Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Shiguang ChenDepartment of Oncology and Vascular Interventional Therapy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, NHC Key Laboratory of Cancer Metabolism, Fuzhou, 350014, China.
Zhuting FangDepartment of Oncology and Vascular Interventional Therapy, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, NHC Key Laboratory of Cancer Metabolism, Fuzhou, 350014, China. ztfang@fjzlhospital.com.ORCID http://orcid.org/0000-0003-3350-2210

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, characterized by complex pathogenesis and immune escape mechanisms. The tumor immune microenvironment plays an increasingly recognized role in tumorigenesis, progression, and treatment. Receptor-interacting serine/threonine-protein kinase 2 (Ripk2) plays a pivotal role in inflammatory responses and immune regulation. This study aimed to investigate the role of Ripk2 in the HCC immune microenvironment, particularly its impact on macrophage function, using a macrophage Ripk2 knockout mouse model (Ripk2

Indexed as

Carcinoma, HepatocellularCD8-Positive T-LymphocytesChemokine CXCL9Liver NeoplasmsReceptor-Interacting Protein Serine-Threonine Kinase 2AnimalsDisease ProgressionHumansMacrophagesMiceMice, Inbred C57BLMice, KnockoutSignal TransductionTumor MicroenvironmentChemokine CXCL9Cxcl9 protein, mouseReceptor-Interacting Protein Serine-Threonine Kinase 2Ripk2 protein, mouse

Identifiers

PMID42215445
PMCPMC13408793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.