Evidence map›Paper›PMID 42215441›Full record

ArticleCell death & disease2026

CREB-SEC61G feedback loop sustains enhanced autophagy and boosts proliferation in PDAC.

Xiao Wu, Xinyan Wu, Yihang Nan, Jianhui Li, Lei Zhuang, Wengang Shan, Song Ge, Kun Tong, Bin Zhang, Qingwei Song and 1 more

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In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xiao Wu *Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.ORCID http://orcid.org/0000-0001-7895-8460
Xinyan Wu *Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yihang Nan *Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Jianhui LiDepartment of Hepatobiliary Surgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Lei ZhuangDepartment of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Wengang ShanDepartment of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Song GeDepartment of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Kun TongDepartment of Anesthesia, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Bin ZhangDepartment of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. zhangbin@xzhmu.edu.cn.ORCID http://orcid.org/0009-0003-1405-1853
Qingwei SongDepartment of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China. sqw521@163.com.ORCID http://orcid.org/0009-0004-9152-4092
Xuhao NiDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China. nixh_doctor@163.com.ORCID http://orcid.org/0000-0003-1550-8408

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82303149National Natural Science Foundation of China (National Science Foundation of China) 82401422
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with rising incidence and mortality rates, in which autophagy plays a pivotal role in promoting tumor survival. Although SEC61G has been reported to be associated with poor outcomes in patients with PDAC, its underlying mechanism remains largely unclear. In the present study, we found that SEC61G was overexpressed in PDAC and correlated with an unfavorable patient prognosis. Further experiments demonstrated the pro-proliferation efficacy of SEC61G in PDAC progression both in vitro and in vivo. Mechanistically, SEC61G enhanced cellular autophagy in PDAC in a Ca

Indexed as

AutophagyCarcinoma, Pancreatic DuctalCyclic AMP Response Element-Binding ProteinMembrane ProteinsPancreatic NeoplasmsAnimalsCalciumCell Line, TumorCell ProliferationFeedback, PhysiologicalGene Expression Regulation, NeoplasticHumansMiceMice, NudePromoter Regions, GeneticSecurinCalciumCREB1 protein, humanCyclic AMP Response Element-Binding ProteinMembrane Proteinspituitary tumor-transforming protein 1, humanSecurin

Identifiers

PMID42215441
PMCPMC13424619

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.