Evidence map›Paper›PMID 42214415›Full record

ArticlePhysics in medicine and biology2026

Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy: implications for personalized toxicity risk stratification.

Thao-Nguyen Pham, Ibrahim Chamseddine, Dorothee Lebhertz, Jean-Claude Quintyn, Harald Paganetti, Juliette Thariat

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thao-Nguyen PhamDepartment of Radiation Oncology, Centre François Baclesse, Caen, Normandy, France.ORCID 0009-0003-9342-6464
Ibrahim ChamseddineDepartment of Radiation Oncology, Mass General Brigham, Harvard Medical School, Boston, United States of America.ORCID 0000-0002-7005-8692
Dorothee LebhertzDepartment of Medical Physics, Centre François Baclesse, Caen, Normandy, France.
Jean-Claude QuintynDepartment of Ophthalmology, Unicaen, University Hospital of Caen, 14033 Caen, France.
Harald PaganettiDepartment of Radiation Oncology, Mass General Brigham, Harvard Medical School, Boston, United States of America.ORCID 0000-0002-6257-2413
Juliette ThariatDepartment of Radiation Oncology, Centre François Baclesse, Caen, Normandy, France.ORCID 0000-0003-4755-496X

Funding

Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers.P01CA261669 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI TITT, UWE · 2021 to 2025
$14.0M
NCI NIH HHS P01 CA261669
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Optic Nerve DiseasesPrecision MedicineProton TherapyRadiation InjuriesAdultAgedBayes TheoremFemaleHumansMaleMiddle AgedRisk AssessmentBayesian networkmodelingproton therapyradiation-induced optic neuropathy

Identifiers

PMID42214415
PMCPMC13577194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.