Evidence map›Paper›PMID 42214391›Full record

ArticleInfection and immunity2026

Understanding the role of pyruvate dehydrogenase in

Matthew J Freeman, Noah J Eral, Abigail M Debrine, David M Stevenson, Daniel Amador-Noguez, John-Demian Sauer

Abstract read
In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew J Freeman *Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Noah J Eral *Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Abigail M DebrineDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
David M StevensonDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Daniel Amador-NoguezDepartment of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-3568-3070
John-Demian SauerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-9367-794X

Funding

INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTST32GM008692 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BURKARD, MARK E · 1998 to 2020
$10.3M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
Identification and Characterization of Genes Required for Listeria monocytogenes Cytosolic SurvivalR01AI184369 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI JOHN-DEMIAN SAUER · 2024 to 2026
$2.1M
Identification of Listeria monocytogenes immune evasion mechanismsR21AI173738 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SAUER, JOHN-DEMIAN · 2023 to 2024
$414k
Burroughs Wellcome Fund PATH AwardNIAID NIH HHS R01 AI184369NIAID NIH HHS R21 AI173738NIAID NIH HHS T32 AI055397NIGMS NIH HHS T32 GM008692NIGMS NIH HHS T32 GM140935NIH HHS R01AI184369NIH HHS R21AI173738NIH HHS T32AI055397NIH HHS T32GM008692
6 · The paper itself

Abstract

Bacterial pathogens must possess finely tuned physiological adaptations to adapt to their infectious niche. One such niche inhabited by

Indexed as

Listeria monocytogenesListeriosisPyruvate Dehydrogenase ComplexAnimalsBacterial ProteinsCytosolMutationVirulenceBacterial ProteinsPyruvate Dehydrogenase ComplexListeria monocytogenesmacrophage cytosolphosphotransferase systemspyruvate dehydrogenase complex

Identifiers

PMID42214391
PMCPMC13367045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.