Evidence map›Paper›PMID 42214366›Full record

ArticleMicrobiology spectrum2026

Facile generation of

Anna M Zaeske, Abigail A Harrington, Timothy J Nickels, Andrew N Gale, Winston Timp, Nicole Alayo, Yasmine Hassoun, David S Perlin, Erika Shor, Kyle W Cunningham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Anna M ZaeskeDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.
Abigail A HarringtonDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.
Timothy J NickelsDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.
Andrew N GaleDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.
Winston TimpDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0003-2083-6027
Nicole AlayoCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Yasmine HassounCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
David S PerlinCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-1268-5524
Erika ShorCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0003-3655-0963
Kyle W CunninghamDepartment of Biology, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-6877-6321

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Critical Factors Influencing Echinocandin Resistance in CandidaglabrataR01AI109025 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PERLIN, DAVID S · 2014 to 2025
$9.8M
Mechanisms Promoting Cellular Tolerance to FungistatsR01AI153414 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CUNNINGHAM, KYLE W · 2020 to 2023
$1.6M
National Institute of Allergy and Infectious Diseases R01-AI109025National Institute of Allergy and Infectious Diseases R01-AI153414NIAID NIH HHS R01 AI109025NIAID NIH HHS R01 AI153414NIGMS NIH HHS T32 GM007231NIGMS NIH HHS T32-GM007231
6 · The paper itself

Abstract

Transposon mutagenesis coupled with deep sequencing (Tn-seq) is currently being deployed in microbial eukaryotes, including the opportunistic yeast pathogen IMPORTANCE: Treatment of fungal infections may be improved by a deeper understanding of the genetic mechanisms of colonization within host organisms. Current approaches to deep genetic sequencing in eukaryotic microbes often involve engineered components that have significant biases, minimize microbial complexity, or alter the normal

Indexed as

Candida glabrataDNA Transposable ElementsMutagenesis, InsertionalAnimalsCandidiasisFungal ProteinsMiceNutrientsDNA Transposable ElementsFungal ProteinsCandida glabrataintestinal colonizationTn-seq

Identifiers

PMID42214366
PMCPMC13340276

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.